The levels of NEFA (oleic acid, palmitic acid, stearic acid, arachidonic acid) were studied in the brain cortex, hypothalamus and the brain stem of rat brain. Inhibition of phospholipase A2 by Delagil (Mepacrinium dichloratum CsL 3) decreased statistically significantly the values of arachidonic aci (-5.5%) in the brain cortex and the values of stearic acid (-11.2%) in the hypothalamua. The cyclooxygenase inhibition by aspirin led to a significant increase of palmitic acid (+12.7%), oleic acid (+18.7%) and arachidonic acid (+14.3%) in the hypothalamus. Total NEFA increased by 11.2%. A significant increase of palmitic acid (+26.9%), arachidonic acid (+33.9%) and of total NEFA (+22.9%) was evidenced in the brain stem. Delagil administered in combination with acetylsalicylic acid suppressed the NEFA increase observed after the application of acetylsalicylic acid alone. A statistically significant decrease was found in stearic acid (-12.6%) in the hypothalamus and in all studied NEFA in the brain stem (palmitic acid, -14.2% stearic acid -11.7%, oleic acid -3.8%, arachidonic acid -16.6% and total NEFA -11.8%).

• MeSH
• Aspirin farmakologie   MeSH
• cyklooxygenasy metabolismus   fyziologie   MeSH
• fosfolipasy A metabolismus   fyziologie   MeSH
• fosfolipasy A2 MeSH
• fosfolipasy fyziologie   MeSH
• inbrední kmeny potkanů MeSH
• inhibitory enzymů farmakologie   MeSH
• krysa rodu Rattus MeSH
• mastné kyseliny metabolismus   MeSH
• mozek účinky léků   metabolismus   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• Aspirin MeSH
• cyklooxygenasy MeSH
• fosfolipasy A MeSH
• fosfolipasy A2 MeSH
• fosfolipasy MeSH
• inhibitory enzymů MeSH
• mastné kyseliny MeSH