The development of the reaction to thermal nociceptive stimulation was studied in neonatal rats of two strains (albino Wistar and pigmented Long-Evans). Using the tail-flick method in neonates of both strains the effects of daily repeated thermal stimulation (sensitisation) were compared to those of acute stimulation applied on 1 day only. During the whole postnatal development period studied (3-28 days) the pigmented rat pups were more sensitive to a repeated thermal nociceptive stimulation than the albinos. The latency of the response did not change linearly during the developmental time studied, but had a pronounced peak (decreased sensitivity) in the period of eye-lid opening. In the pigmented animals the peak appeared 1 day earlier than in the albinos. At the time of the weaning period the latencies of the response were again shorter.

• MeSH
• druhová specificita MeSH
• krysa rodu Rattus MeSH
• nociceptory růst a vývoj   fyziologie   MeSH
• novorozená zvířata MeSH
• ocas MeSH
• potkani Long-Evans MeSH
• potkani Wistar MeSH
• práh bolesti fyziologie   MeSH
• reakční čas fyziologie   MeSH
• vysoká teplota MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH