central nervous system Dotaz Zobrazit nápovědu

Disease-modifying therapies for relapsing multiple sclerosis reduce relapse rates by suppressing peripheral immune cells but have limited efficacy in progressive forms of the disease where cells in the central nervous system play a critical role. To our knowledge, alemtuzumab, fumarates (dimethyl, diroximel, and monomethyl), glatiramer acetates, interferons, mitoxantrone, natalizumab, ocrelizumab, ofatumumab, and teriflunomide are either limited to the periphery or insufficiently studied to confirm direct central nervous system effects in participants with multiple sclerosis. In contrast, cladribine and sphingosine 1-phosphate receptor modulators (fingolimod, ozanimod, ponesimod, and siponimod) are central nervous system-penetrant and could have beneficial direct central nervous system properties.

Klíčová slova
central nervous system, cladribine, fingolimod hydrochloride, multiple sclerosis, ozanimod, ponesimod, siponimod, sphingosine 1 phosphate receptor modulators,
MeSH
imunosupresiva MeSH
kladribin MeSH
lidé MeSH
nemoci centrálního nervového systému * MeSH
relabující-remitující roztroušená skleróza * MeSH
roztroušená skleróza * farmakoterapie MeSH
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lidé MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
přehledy MeSH
Názvy látek
imunosupresiva MeSH
kladribin MeSH

Článek

The Role of miR-20 in Health and Disease of the Central Nervous System

Current understanding of the mechanisms underlying central nervous system (CNS) injury is limited, and ...

Cells. 2022 May 03 ; 11 (9) : . [epub] 20220503

ISSN 2073-4409
Zdroj

Current understanding of the mechanisms underlying central nervous system (CNS) injury is limited, and traditional therapeutic methods lack a molecular approach either to prevent acute phase or secondary damage, or to support restorative mechanisms in the nervous tissue. microRNAs (miRNAs) are endogenous, non-coding RNA molecules that have recently been discovered as fundamental and post-transcriptional regulators of gene expression. The capacity of microRNAs to regulate the cell state and function through post-transcriptionally silencing hundreds of genes are being acknowledged as an important factor in the pathophysiology of both acute and chronic CNS injuries. In this study, we have summarized the knowledge concerning the pathophysiology of several neurological disorders, and the role of most canonical miRNAs in their development. We have focused on the miR-20, the miR-17~92 family to which miR-20 belongs, and their function in the normal development and disease of the CNS.

Klíčová slova
central nervous system, miR-20a, microRNA,
MeSH
centrální nervový systém metabolismus MeSH
lidé MeSH
mikro RNA * genetika metabolismus MeSH
nemoci nervového systému * metabolismus MeSH
poranění nervového systému * metabolismus MeSH
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lidé MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
přehledy MeSH
Názvy látek
mikro RNA * MeSH

Článek

News in WHO 2021 classification of tumours of the central nervous system

A significant change is the new grading system for these tumours, including the innovative involvement ...

Ceskoslovenska patologie. 2022 Fall ; 58 (3) : 126-134.

Cesk Patol
ISSN 1210-7875
Zdroj

The aim of the presented communication is to clearly inform the general professional public about the newly approved modifications in this classification, including the newly approved types of tumours. A significant change is the new grading system for these tumours, including the innovative involvement of tumour profiling at the molecular level in the system for determining the degree of tumour differentiation and the application of the principle of integrated diagnostics, i. e. the synthesis of available histopathological and molecular findings in CNS tumors.