• Klíčová slova
• LIGAMENTS/diseases *, OSSIFICATION/in infancy and childhood *,
• MeSH
• artritida * MeSH
• dítě MeSH
• fascie * MeSH
• heterotopická osifikace * MeSH
• kojenec MeSH
• lidé MeSH
• ligamenta * MeSH
• ligamentum patellae * MeSH
• nemoc * MeSH
• osteogeneze * MeSH
• Check Tag
• dítě MeSH
• kojenec MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• Klíčová slova
• OSSIFICATION *,
• MeSH
• heterotopická osifikace * MeSH
• lidé MeSH
• osteogeneze * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• Klíčová slova
• EPIPHYSES *, GROWTH *, HAND *, OSSIFICATION *, PUBERTY *,
• MeSH
• epifýzy * MeSH
• fyziologické jevy * MeSH
• heterotopická osifikace * MeSH
• lidé MeSH
• osteogeneze * MeSH
• pohlavní dospělost * MeSH
• puberta * MeSH
• ruka * MeSH
• růst * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Heterotopic ossification (HO) denotes aberrant osteogenesis in extra-skeletal tissues, often associated with neurological disorders, total hip arthroplasty, and specific traumatic scenarios. Neurogenic heterotopic ossification manifests prominently subsequent to traumatic brain injury or spinal cord injury, with Guillain-Barre Syndrome presenting an infrequent etiological link. This article details the case of a 56-year-old female diagnosed with Guillain-Barre Syndrome, who developed neurogenic heterotopic ossification around both hips within two years of disease onset. The patient's medical history included mechanical ventilation, incomplete tetraplegia, and prolonged immobilization. A conclusive diagnosis of HO was established through radiological and clinical assessments. After neurogenic heterotopic ossification was confirmed, the patient had surgery to remove the lesions, radiation therapy, and medication treatments as planned. Physical therapy was introduced one week post-surgery, with subsequent follow-ups tracking improvements in pain levels, range of motion (ROM), and Activities of Daily Living scores. Key words: neurogenic heterotopic ossification, Guillain-Barre syndrome, hip, excision.

• MeSH
• Guillainův-Barrého syndrom komplikace   diagnóza   terapie   MeSH
• heterotopická osifikace * etiologie   diagnóza   MeSH
• kyčelní kloub * diagnostické zobrazování   chirurgie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• rozsah kloubních pohybů MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

• MeSH
• fluoridy škodlivé účinky   MeSH
• heterotopická osifikace chemicky indukované   diagnostické zobrazování   MeSH
• lidé MeSH
• ligamenta diagnostické zobrazování   účinky léků   MeSH
• radiografie MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• fluoridy MeSH

• Klíčová slova
• HYOID BONE *, OSSIFICATION *,
• MeSH
• heterotopická osifikace * MeSH
• larynx * MeSH
• lidé MeSH
• os hyoideum * MeSH
• osteogeneze * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Material-induced ossification is suggested as a suitable approach to heal large bone defects. Fiber-reinforced composite-bioactive glasses (FRC-BGs) display properties that could enhance the ossification of calvarial defects. Here, we analyzed the healing processes of a FRC-BG implant in vivo from the perspective of material-induced ossification. Histological analysis of the implant, which was removed 5 months after insertion, showed the formation of viable, noninflammatory mesenchymal tissue with newly-formed mineralized woven bone, as well as nonmineralized connective tissue with capillaries and larger blood vessels. The presence of osteocytes was detected within the newly generated bone matrix. To expand our understanding on the osteogenic properties of FRC-BG, we cultured human adipose tissue-derived mesenchymal stromal cells (AD-MSCs) in the presence of two different BGs (45S5 and S53P4) and Al2 O3 control. AD-MSCs grew and proliferated on all the scaffolds tested, as well as secreted abundant extracellular matrix, when osteogenic differentiation was appropriately stimulated. 45S5 and S53P4 induced enhanced expression of COL2A1, COL10A1, COL5A1 collagen subunits, and pro-osteogenic genes BMP2 and BMP4. The concomitant downregulation of BMP3 was also detected. Our findings show that FRC-BG can support the vascularization of the implant and the formation of abundant connective tissue in vivo. Specifically, BG 45S5 and BG S53P4 are suited to evoke the osteogenic potential of host mesenchymal stromal cells. In conclusion, FRC-BG implant demonstrated material-induced ossification both in vitro and in vivo.

• Klíčová slova
• bioactive glass, bioactivity, biomaterial-induced ossification, cranial implant, fiber-reinforced composite, osteogenesis,
• MeSH
• biokompatibilní materiály aplikace a dávkování   MeSH
• lebka zranění   metabolismus   MeSH
• lidé středního věku MeSH
• lidé MeSH
• osteogeneze účinky léků   MeSH
• protézy a implantáty * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• biokompatibilní materiály MeSH

This case presents the utility of ultrasound examination in diagnostics, providing accurate therapy and follow-up of entrapment syndrome of the ulnar nerve, caused by heterotopic ossification. The heterotopic ossifications were in this case presumably linked to a long-term working with a vibration sander.

• MeSH
• heterotopická osifikace komplikace   MeSH
• lidé MeSH
• senioři MeSH
• syndrom kubitálního tunelu diagnostické zobrazování   etiologie   MeSH
• ultrasonografie MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• dopisy MeSH
• kazuistiky MeSH

• Klíčová slova
• OSSIFICATION *,
• MeSH
• heterotopická osifikace * MeSH
• lidé MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

PURPOSE: Cubital tunnel syndrome is a well-described entity with many reported etiologies and anatomical compression sites. Accessory ossicles of either traumatic or congenital origin might occur around the elbow joint. Only one case reporting such ossicles compressing the ulnar nerve exists in previous literature. We aim to present this entity with a detailed description of the patient history and treatment. CASE REPORT: We report a case of 30-year-old female presenting with classical signs of cubital tunnel syndrome-positive Wartenberg's and Froment's signs, hypoesthesia in the fourth and fifth finger with decreased finger duction strength but without gross hypotrophy of interosseous and hypothenar muscles. Tinel's sign was positive over the ulnar sulcus and an accessory ossicle was found on the elbow radiograph within the ulnar sulcus. The first signs of calcification in this patient were reported 6 years prior in a follow-up after the dislocation of her elbow joint following a bike accident. The EMG confirmed ulnar nerve neuropathy in the elbow area. The ossicle was extirpated, the ulnar nerve was decompressed in the ulnar sulcus in a standard manner and the symptoms quickly resolved. The patient has been regularly visiting our outpatient clinic for the next 12 years without any complaints considering her elbow and the ulnar nerve. CONCLUSION: This is a rare case of cubital tunnel syndrome caused by an accessory ossicle of traumatic origin. Simple bone extirpation with ulnar nerve release followed by anterior subcutaneous transposition is the recommended method of treatment. No report of congenital accessory bones causing ulnar nerve compression in the elbow exists in the literature.

• Klíčová slova
• Accessory bones, Cubital tunnel syndrome, Pathologic ossification, Ulnar nerve neuropathy,
• MeSH
• dospělí MeSH
• heterotopická osifikace * diagnóza   diagnostické zobrazování   MeSH
• lidé MeSH
• loket MeSH
• loketní kloub * fyziologie   MeSH
• nervus ulnaris MeSH
• syndrom kubitálního tunelu * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH