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Sinonasal SMARCB1 (INI1) Deficient Carcinoma With Yolk Sac Tumor Differentiation: Report of a Case and Comparison With INI1 Expression in Gonadal Germ Cell Tumors
M. Zamecnik, J. Rychnovsky, J. Syrovatka,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu kazuistiky, časopisecké články
PubMed
29166820
DOI
10.1177/1066896917741549
Knihovny.cz E-zdroje
- MeSH
- buněčná diferenciace MeSH
- dospělí MeSH
- gen SMARCB1 analýza biosyntéza MeSH
- germinální a embryonální nádory metabolismus MeSH
- karcinom metabolismus patologie MeSH
- lidé MeSH
- nádor z entodermálního sinusu patologie MeSH
- nádorové biomarkery analýza MeSH
- nádory sinu maxillaris metabolismus patologie MeSH
- nádory vaječníků metabolismus MeSH
- testikulární nádory metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
SMARCB1 (INI1) deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. We present a case of this carcinoma that contained, in addition to a "common" morphology, scattered foci of yolk sac tumor differentiation. The tumor occurred in paranasal sinuses in a 44-year-old woman. Immunohistochemically, it was diffusely negative for INI1, whereas an expression of yolk sac tumor markers (α-fetoprotein, glypican-3, CDX2) was limited to the yolk sac tumor component. For comparison with the present case, we performed INI1 immunostaining on a series of 11 gonadal germ cell tumors with yolk sac tumor differentiation. All of these cases showed strong and diffuse expression of INI1, in contrast with the present sinonasal tumor. Our findings expand the morphologic spectrum of SMARCB1 (INI1) deficient sinonasal carcinoma. In addition, we show preliminarily that gonadal germ cell tumors with yolk sac tumor differentiation are not SMARCB1/INI1-deficient.
Department of Otorhinolaryngology Head and Neck Surgery Agel Hospital Novy Jicin Czech Republic
Department of Pathology Agel Laboratories a s Novy Jicin Czech Republic
Citace poskytuje Crossref.org
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