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Laboratory Parameters Associated With Inflammation Do Not Affect PD-L1 Expression in Non-small Cell Lung Cancer

M. Svaton, M. Drosslerova, O. Fischer, M. Marel, M. Hrnciarik, O. Venclicek, P. Zuna, M. Svoboda, J. Blazek, M. Bratova, A. Mullerova, B. Vankova, D. Krejci

. 2022 ; 42 (3) : 1563-1569. [pub] -

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22010815

BACKGROUND/AIM: Due to some interconnectedness at the molecular level, this study assessed the possible influence of laboratory parameters associated with systemic inflammatory environment on programmed death-ligand 1 (PD-L1) expression in non-small cell lung carcinoma (NSCLC). PATIENTS AND METHODS: We assessed effects of c-reactive protein (CRP), albumin, haemoglobin, neutrophil, and lymphocyte levels on PD-L1 expression in NSCLC. Patient data were obtained retrospectively from LUCAS, the Czech registry of patients with lung carcinomas. Correlations of two continuous parameters (PD-L1 expression and laboratory parameters) were analysed by correlation coefficient. Differences in continuous parameters between two or more groups were tested by Mann-Whitney or Kruskal-Wallis tests. Independence of two categorical parameters was tested by chi-square test. RESULTS: We demonstrated no influence of the investigated laboratory parameters on PD-L1 expression in NSCLC, either in continuous or categorical division of variables. CONCLUSION: Inflammatory laboratory parameters at time of NSCLC diagnosis are unlikely to affect the determination of PD-L1 expression.

Citace poskytuje Crossref.org

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$a Drosslerova, Marie $u Department of Respiratory Medicine, Thomayer Hospital, Prague, Czech Republic
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$a Marel, Miloslav $u Department of Pneumology, 2 Faculty of Medicine, Charles University, Prague, Czech Republic
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