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To the ring-shaped nucleolus seen by microscopy using human lymphocytes of blood donors and chronic lymphocytic leukemia patients
K. Smetana, D. Mikulenková, J. Karban, M. Trněný
Jazyk angličtina Země Itálie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2010
Free Medical Journals
od 2000
PubMed Central
od 2009
Europe PubMed Central
od 2009
Open Access Digital Library
od 2003-01-01
Open Access Digital Library
od 2009-01-01
Medline Complete (EBSCOhost)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2000
PubMed
39221853
DOI
10.4081/ejh.2024.4075
Knihovny.cz E-zdroje
- MeSH
- buněčné jadérko * ultrastruktura patologie MeSH
- chronická lymfatická leukemie * patologie MeSH
- dárci krve * MeSH
- lidé MeSH
- lymfocyty * patologie MeSH
- RNA MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The present study was undertaken to provide more information on the peripheral RNA containing ring of ringshaped nucleoli (RSNo). Human lymphocytes of blood donors and patients suffering from B chronic lymphocytic leukemia mostly characterized by RSNo represented very convenient cell models for such study. According to the light microscopy the peripheral RNA ring possessed several highly condensed foci. Such regions represented accumulated dense RNA fibrillar components (DFCs) seen by the electron microscopy. In contrary, the incidence of dense granular RNA-containing components (GCs) in surrounding portions of the RNA ring was small. Thus, the structural and morphological organization of the peripheral RNA ring of RSNo apparently reflects sites of micro-segregated foci of DFCs and a small incidence of GCs. That structural organization of the peripheral RNA ring of RSNo appeared to be a prerequisite for further regressive nucleolar changes resulting in the development of micronucleoli in terminal lymphocytes.
Citace poskytuje Crossref.org
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