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Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study
S. Anastasopoulou, G. Swann, L. Andres-Jensen, A. Attarbaschi, S. Barzilai-Birenboim, DJ. Erdelyi, G. Escherich, L. Hamadeh, A. Harila, E. Lopez-Lopez, S. McGowan, A. Möricke, C. Putti, JC. Sagi, K. Schmiegelow, NJ. Ullrich, IM. van der Sluis,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, pozorovací studie
Grantová podpora
TJ2020-0082
Swedish Childhood Cancer Fund (Barncancerfonden)
TJ2019-0031
Swedish Childhood Cancer Fund (Barncancerfonden)
2014/170
Children with Cancer UK
Schiehallion Childrens Cancer and Leukaemia Fund
DRCPFA-Nov21\100001
Cancer Research UK (Programme Foundation Award)
GCHC/PSG/2016/11
Glasgow Children's Hospital Charity
00064203
MH CZ - DRO Motol University Hospital, Prague, Czech Republic
CTRQQR-2021\100006
CRUK Scotland Centre
PubMed
38924051
DOI
10.1111/bjh.19610
Knihovny.cz E-zdroje
- MeSH
- akutní lymfatická leukemie * farmakoterapie MeSH
- dexamethason škodlivé účinky terapeutické užití aplikace a dávkování MeSH
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- neurotoxické syndromy etiologie MeSH
- předškolní dítě MeSH
- protokoly protinádorové kombinované chemoterapie škodlivé účinky terapeutické užití MeSH
- steroidy terapeutické užití škodlivé účinky MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
Steroids are a mainstay in the treatment of acute lymphoblastic leukaemia (ALL) in children and adolescents; however, their use can cause clinically significant steroid-related neuropsychiatric symptoms (SRNS). As current knowledge on SRNS during ALL treatment is limited, we mapped the phenotypes, occurrence and treatment strategies using a database created by the international Ponte di Legno Neurotoxicity Working Group including data on toxicity in the central nervous system (CNS) in patients treated with frontline ALL protocols between 2000 and 2017. Ninety-four of 1813 patients in the CNS toxicity database (5.2%) experienced clinically significant SRNS with two peaks: one during induction and one during intensification phase. Dexamethasone was implicated in 86% of SRNS episodes. The most common symptoms were psychosis (52%), agitation (44%) and aggression (31%). Pharmacological treatment, mainly antipsychotics and benzodiazepines, was given to 87% of patients while 38% were hospitalised due to their symptoms. Recurrence of symptoms was reported in 29% of patients and two previously healthy patients required ongoing pharmacological treatment at the last follow up. Awareness of SRNS during ALL treatment and recommendation on treatment strategies merit further studies and consensus.
Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden
Department of Genetics Cell and Immunobiology Semmelweis University Budapest Hungary
Department of Neurology Boston Children's Hospital Harvard Medical School Boston Massachusetts USA
Department of Paediatrics Semmelweis University Budapest Hungary
Department of Women's and Children's Health Uppsala University Uppsala Sweden
Institute of Clinical Medicine Faculty of Medicine University of Copenhagen Copenhagen Denmark
Institute of Genomic Medicine and Rare Disorders Semmelweis University Budapest Hungary
Maccabi Healthcare Services and Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel
Pediatric Oncology Group Biobizkaia Health Research Institute Barakaldo Spain
Princess Maxima Center for Pedatric Oncology Utrecht the Netherlands
St Anna Children's Cancer Research Institute Vienna Austria
University of Texas Southwestern Medical Center Dallas Texas USA
Citace poskytuje Crossref.org
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