Evaluation and implementation of behavioral and educational tools that improves the patients' intentional and unintentional non-adherence to cardiovascular medications in family medicine clinics
Status PubMed-not-MEDLINE Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27013911
PubMed Central
PMC4792890
DOI
10.1016/j.jsps.2015.02.022
PII: S1319-0164(15)00060-2
Knihovny.cz E-zdroje
- Klíčová slova
- Adherence, Cardiovascular diseases, Cardiovascular medications, Non-adherence,
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: There are limited number of studies describing the reasons and interventions of non-adherence to cardiovascular medications in United Arab Emirates (UAE). We aimed to implement and evaluate the behavioral and educational tools that indicate the reasons of non-adherence in patients with cardiovascular diseases and improve patient's adherence to their cardiovascular medications. METHODS: In this prospective interventional study, we recruited patients (n = 300) with cardiovascular diseases from three family medicine clinics in Al Ain, UAE in 2010. We assessed patients' responses to a validated brief medication questionnaire (BMQ). RESULTS: At the end of the study, we observed a significant improvement in adherence. When we compared pre- and post-interventions, the mean (± standard deviation, SD) score for non-adherence to current regimen were 4.1 ± 0.2 vs. 3.0 ± 0.3 (p = 0.034); indication of negative believes or motivational barriers scores was 1.8 ± 0.4 vs. 0.9 ± 0.1 (p = 0.027); the indication of recall barrier scores was 1.6 ± 0.1 vs. 0.8 ± 0.1 (p = 0.014); and the indication of access barrier scores was 1.6 ± 0.2 vs. 0.7 ± 0.2 (p = 0.019). Mean blood pressure, fasting blood glucose, glycosylated hemoglobin, low density lipoprotein and postprandial blood glucose decreased significantly (p < 0.01) post-intervention. CONCLUSION: We reported that implemented multifaceted tools targeting patients, provider and healthcare system have improved the adherence to cardiovascular medications. Our interventions managed to improve patients' clinical outcome via improving adherence to prescribed cardiovascular medications.
Ajman University of Sciences and Technology Ajman United Arab Emirates
Al Ain Hospital Abu Dhabi Health Services Company Al Ain United Arab Emirates
Charles University Hradec Kralove Czech Republic
College of Medicine and Health Sciences Al Ain United Arab Emirates
College of Medicine and Health Sciences United Arab Emirates
Hacettepe University Sihhiye 06100 Ankara Turkey
Ministry of Health Nyala South Sudan
Tawam Hospital Abu Dhabi Health Services Company Abu Dhabi United Arab Emirates
University of Gondar College of Medicine and Health Sciences Gondar Ethiopia
Zobrazit více v PubMed
Al-Qasem A., Smith F., Clifford S. Adherence to medication among chronic patients in Middle Eastern countries: review of studies. East Mediter. Health J. 2011;17:4. PubMed
Andrew M.P., Liza T., Finley R. Meta-analysis of trials of interventions to improve medication adherence. Am. SocHealth-Syst. Pharm. 2003;60:657–665. PubMed
Beardon P.H., McGilchrist M.M., McKendrick A.D. Primary non-compliance with prescribed medication in primary care. BMJ. 1993;307:846–848. PubMed PMC
Black H.R. Will better-tolerated antihypertensive agents improve blood pressure control? JNC VI revisited. Am. J. Hypertens. 1999;12:225S–230S. PubMed
Castellano J.M., Sanz G., Fernandez Ortiz A., Garrido E., Bansilal S., Fuster V. A poly pill strategy to improve global secondary cardiovascular prevention: from concept to reality. J. Am. Coll. Cardiol. 2014;64:613–621. PubMed
Castellano J.M., Sanz G., Peñalvo J.L., Bansilal S., Fernández-Ortiz A., Alvarez L., Guzmán L., Linares J.C., García F., D’Aniello F., Arnáiz J.A., Varea S., Martínez F., Lorenzatti A., Imaz I., Sánchez-Gómez L.M., Roncaglioni M.C., Baviera M., Smith S.C., Jr., Taubert K., Pocock S., Brotons C., Farkouh M.E., Fuster V. A polypill strategy to improve adherence: results from the FOCUS project. J. Am. Coll. Cardiol. 2014;64:2071–2082. PubMed
Cherry D.K., Hing E., Woodwell D.A., Rechtsteiner E.A. National Ambulatory Medical Care Survey: 2006 summary. Nat. Health Stat. Rep. 2008;3:1–39. PubMed
Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo J.L., Jr, Jones D.W., Materson B.J., Oparil S., Wright J.T., Jr., Roccella E.J. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42:1206–1252. PubMed
Corrao G., Zambon A., Parodi A., Poluzzi E., Baldi I., Merlino L., Cesana G., Mancia G. Discontinuation of and changes in drug therapy for hypertension among newly-treated patients: a population-based study in Italy. J. Hypertens. 2008;26:819–824. PubMed
Craghead R., Wartski D. An evaluative study of unclaimed prescriptions. Hosp. Pharm. 1991;26:616–617. PubMed
Dezii C.M. A retrospective study of persistence with single-pill combination therapy vs. concurrent two-pill therapy in patients with hypertension. Manage Care. 2000;9:S2–S6. PubMed
Elnour A., Shehab A., Sadiq A., Ellahham N.H. Monitoring the Doctors’ prescribing patterns in outpatient polyclinic setting: the clinical pharmacist’s approach. Khartoum. Pharm. J. 2008;11:6–11.
Fincham J.E., Wertheimer A.J. Elderly patient initial non-compliance: the drugs and reasons. J. Geriat. Drug Ther. 1988;2:53–62.
Go A.S., Mozaffarian D., Roger V.L., Benjamin E.J., Berry J.D., Borden W.B., Bravata D.M., Dai S., Ford E.S., Fox C.S., Franco S., Fullerton H.J., Gillespie C., Hailpern S.M., Heit J.A., Howard V.J., Huffman M.D., Kissela B.M., Kittner S.J., Lackland D.T., Lichtman J.H., Lisabeth L.D., Magid D., Marcus G.M., Marelli A., Matchar D.B., McGuire D.K., Mohler E.R., Moy C.S., Mussolino M.E., Nichol G., Paynter N.P., Schreiner P.J., Sorlie P.D., Stein J., Turan T.N., Virani S.S., Wong N.D., Woo D., Turner M.B. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics–2013 update: a report from the American Heart Association. Circulation. 2013;127:e6–e245. PubMed PMC
Golin C.E., Liu H., Hays R.D., Miller L.G., Beck C.K., Ickovics J., Kaplan A.H., Wenger N.S. A prospective study of predictors of adherence to combination antiretroviral medication. J. Gen. Intern. Med. 2002;17:756–765. PubMed PMC
Haynes R.B., Ackloo E., Sahota N., McDonald H.P., Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008;2 CD000011. PubMed
Jackevicius Cynthia A., Mamdani M., Tu J.V. Adherence with statins in patients with and without acute coronary syndromes. JAMA. 2002;288:463–467. PubMed
Jackevicius C.A., Paterson J.M., Naglie G. Concordance between discharge prescriptions and insurance claims in post-myocardial infarction patients. Pharmacoepidem. Drug Safety. 2007;16:207–215. PubMed
Jackevicius C.A., Ping Li, Tu J.V. Prevalence, predictors, and outcomes of primary nonadherence after acute myocardial infarction. Circulation. 2008;117:1028–1036. PubMed
James P.A., Oparil S., Carter B.L., Cushman W.C., Dennison-Himmelfarb C., Handler J., Lackland D.T., LeFevre M.L., MacKenzie T.D., Ogedegbe O., Smith S.C., Jr, Svetkey L.P., Taler S.J., Townsend R.R., Wright J.T., Jr., Narva A.S., Ortiz E. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8) JAMA. 2014;311:507–520. PubMed
Kirking M.H., Zaleon C.R., Kirking D.M. Unclaimed prescriptions at a university hospital’s ambulatory care pharmacy. Am. Soc. Health-Sys. Pharm. 1995;52:490–495. PubMed
LaFleur J., Oderda G.M. Methods to measure patient compliance with medication regimens. J. Pain Palliat. Care Pharmacother. 2004;18:81–87. PubMed
Mini K.V., Adepu Ramesh, Parthasarathi G., Mothi S.N., Swamy V.T. Impact of pharmacist provided education on medication adherence behavior in HIV/AIDS patients treated at a non-government secondary care hospital in India. J. AIDSHIV Res. 2012;4:94–99.
Moise N., Schwartz J., Bring R., Shimbo D., Kronish I.M. Antihypertensive drug class and adherence: an electronic monitoring study. Am. J. Hypertens. 2014 pii: hpu199. PubMed PMC
Monane M., Bohn R.L., Gurwitz J.H., Glynn R.J., Levin R., Avorn J. Compliance with antihypertensive therapy among elderly Medicaid enrollees: the roles of age, gender, and race. Am. J. Public Health. 1996;86:1805–1808. PubMed PMC
Munger M.A., Van Tassell B.W., LaFleur J. Medication nonadherence: an unrecognized cardiovascular risk factor. Meds. Gen. Med. 2007;9:58. PubMed PMC
Murphy D.A., Sarr M., Durako S.J., Moscicki A.B., Wilson C.M., Muenz L.R. Adolescent medicine HIV/AIDS research network. Barriers to HAART adherence among human immunodeficiency virus-infected adolescents. Arch. Ped. Adolesc Med. 2003;157:249–255. PubMed
Osterberg L., Blaschke T. Adherence to medication. New Engl. J. Med. 2005;353:487–497. PubMed
Rasmussen J.N., Chong A., Alter D.A. Relationship between adherence to evidence-based pharmacotherapy and long term mortality after acute myocardial infarction. JAMA. 2007;297:177–186. PubMed
Skutnik S., Katsanis L.P. The impact of initial noncompliance in Canadian retail pharmacies: a descriptive examination. J. Pharmac. Mark Manag. 1997;11:35–54.
Stone V.E., Hogan J.W., Schuman P., Rompalo A.M., Howard A.A., Korkontzelou C., Smith D.K. HERS STUDY. Antiretroviral regimen complexity, self-reported adherence, and HIV patients’ understanding of their regimens: survey of women in the HER study. J. Acquir. Imm. Def. Synd. 2001;28:124–131. PubMed
Svarstad B.L., Chewning B.A., Sleath B.L., Claesson C. The brief medication questionnaire: a tool for screening patient adherence and barriers to adherence. Patient Educ. Counsel. 1999;37:113–124. PubMed
Thom T., Haase N., Rosamond W., Howard V.J., Rumsfeld J., Manolio T., Zheng Z.J., Flegal K., O’Donnell C., Kittner S., Lloyd-Jones D., Goff D.C., Jr., Hong Y., Adams R., Friday G., Furie K., Gorelick P., Kissela B., Marler J., Meigs J., Roger V., Sidney S., Sorlie P., Steinberger J., Wasserthiel-Smoller S., Wilson M., Wolf P. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics–2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006;113:e85–e151. PubMed
Wang P.S., Avorn J., Brookhart M.A., Mogun H., Schneeweiss S., Fischer M.A., Glynn R.J. Effects of non cardiovascular comorbidities on antihypertensive use in elderly hypertensives. Hypertension. 2005;46:273–279. PubMed
World Health Organization, 2003. Adherence to Long-Term Therapies: Evidence for Action. Geneva: WHO. from: <http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf>. (Accessed 29.12.14).