Department of Pediatrics Faculty of Medicine and Dentistry Palacky University and University Hospital Olomouc Olomouc Czech Republic

Institute of Cancer and Genomic Sciences University of Birmingham

Institute of Cancer and Genomic Sciences University of Birmingham Birmingham

Institute of Cancer and Genomic Sciences University of Birmingham Birmingham United Kingdom; National Institute for Health Research Birmingham Biomedical Research Centre University of Birmingham Birmingham

Institute of Cancer and Genomic Sciences University of Birmingham Birmingham United Kingdom; The Palatine Centre Durham University Durham

Institute of Immunology and Immunotherapy University of Birmingham Birmingham

Institute of Immunology and Immunotherapy University of Birmingham Birmingham United Kingdom; Royal College of Surgeons in Ireland Medical University of Bahrain Manama PO Box 15503 Bahrain

Limerick Digital Cancer Research Centre Bernal Institute and Health Research Institute and School of Medicine University of Limerick Limerick

Limerick Digital Cancer Research Centre Bernal Institute and Health Research Institute and School of Medicine University of Limerick Limerick Ireland; Royal College of Surgeons in Ireland Medical University of Bahrain Manama Bahrain; Department of Clinical and Molecular Pathology Institute of Molecular and Translational Medicine Faculty of Medicine and Dentistry Palacky University and University Hospital Olomouc Olomouc

University Hospitals Plymouth NHS Trust Plymouth

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Taylor GS, Long HM, Brooks JM, Rickinson AB, Hislop AD. The immunology of Epstein-Barr virus-induced disease. Ann Rev Immunol. 2015;33:787-821. PubMed

Lee SP, Constandinou CM, Thomas WA, et al. . Antigen presenting phenotype of Hodgkin Reed-Sternberg cells: analysis of the HLA class I processing pathway and the effects of interleukin-10 on Epstein-Barr virus-specific cytotoxic T-cell recognition. Blood. 1998;92(3):1020-1030. PubMed

Frisan T, Sjoberg J, Dolcetti R, et al. . Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin’s disease. Blood. 1995;86(4):1493-1501. PubMed

Tan KL, Scott DW, Hong F, et al. . Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial. Blood. 2012;120(16):3280-3287. PubMed PMC

Carey CD, Gusenleitner D, Lipschitz M, et al. . Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma. Blood. 2017;130(22):2420-2430. PubMed PMC

Armand P, Engert A, Younes A, et al. . Nivolumab for relapsed/ refractory classic Hodgkin lymphoma after failure of autologous hematopoietic cell transplantation: extended follow-up of the multicohort single-arm phase II CheckMate 205 Trial. J Clin Oncol. 2018;36(14):1428-1439. PubMed PMC

Taya M, Hammes SR. Glycoprotein non-metastatic melanoma protein B (GPNMB) and cancer: a novel potential therapeutic target. Steroids. 2018;133:102-107. PubMed PMC

Chung JS, Sato K, Dougherty II, Cruz PD, Ariizumi K. DC-HIL is a negative regulator of T lymphocyte activation. Blood. 2007;109(10):4320-4327. PubMed PMC

Xiong A, Zhang J, Chen Y, Zhang Y, Yang F. Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM. EBioMedicine. 2022;83:104239. PubMed PMC

Chung JS Tamura K Akiyoshi H Cruz PD, Jr., Ariizumi K.. The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells. J Immunol. 2014;192(6):2576-2584. PubMed PMC

Tomihari M, Chung JS, Akiyoshi H, Cruz PD, Ariizumi K. DC-HIL/glycoprotein Nmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells. Cancer Res. 2010;70(14):5778-5787. PubMed PMC

Sakano Y, Noda T, Kobayashi S, et al. . Tumor endothelial cell-induced CD8(+) T-cell exhaustion via GPNMB in hepatocellular carcinoma. Cancer Sci. 2022;113(5):1625-1638. PubMed PMC

Chung JS, Tamura K, Cruz PD, Ariizumi K. DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth. J Invest Dermatol. 2014;134(11):2784-2794. PubMed PMC

Silva WN, Prazeres P, Paiva AE, et al. . Macrophage-derived GPNMB accelerates skin healing. Exp Dermatol. 2018;27(6):630-635. PubMed PMC

Ramani V, Chung JS, Ariizumi K, Cruz PD, Soluble DC-HIL/ Gpnmb modulates T-lymphocyte extravasation to inflamed skin. J Invest Dermatol. 2022;142(5):1372-1380. PubMed

Chung JS, Ramani V, Kobayashi M, et al. . DC-HIL/Gpnmb is a negative regulator of tumor response to immune checkpoint inhibitors. Clin Cancer Res. 2020;26(6):1449-1459. PubMed

Cortese N, Carriero R, Barbagallo M, et al. . High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis. Cancer Immunol Res. 2023;11(4):405-420. PubMed PMC