Partial sacrectomy with en bloc tumor resection without instrumentation. What level is safe?

. 2025 ; 5 () : 104246. [epub] 20250327

Status PubMed-not-MEDLINE Jazyk angličtina Země Nizozemsko Médium electronic-ecollection

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid40235470
Odkazy

PubMed 40235470
PubMed Central PMC11999580
DOI 10.1016/j.bas.2025.104246
PII: S2772-5294(25)00065-7
Knihovny.cz E-zdroje

INTRODUCTION: En bloc sacrectomy is an extensive surgical procedure which is often the only option which provides cure. Our experience shows that, in selected cases, instrumentation is not necessary even in case of a high en bloc sacrectomy retaining the cranial part of the sacrum in situ. This creates suitable conditions for subsequent proton therapy. RESEARCH QUESTION: What level of resection is safe without reconstruction? MATERIAL AND METHODS: Between 2014 and 2023 we performed a total of 29 sacral resections for various etiologies. Patients following reconstruction of the lumbosacral region by internal fixator (3) and patient after hemicorporectomy (1) were excluded from the study. The study group comprised 25 patients, 15 men and 10 women with a mean age of 45.1 years (range, 1.7-72.2 years). The most frequent indication for surgery was chordoma (8), followed by MPNST (4), yolk sac tumor (2) and undifferentiated sarcoma (2). RESULTS: Stress fractures of the sacral stump occur in elderly patients with lower bone mineral density, or in younger patients with a higher bone mineral density who are more active when resuming their daily routine after the operation. DISCUSSION AND CONCLUSION: Instrumentation is, in our view, primarily indicated in younger and more active patients, whereas in most cases, even with lower bone mineral density, non-instrumented procedure results in sufficient stability in all levels of partial resection.

Zobrazit více v PubMed

Bederman S.S., Shah K.N., Hassan J.M., Hoang B.H., Kiester P.D., Bhatia N.N. Surgical techniques for spinopelvic reconstruction following total sacrectomy: a systematic review. Eur. Spine J. 2014;23(2):305–319. doi: 10.1007/s00586-013-3075-z. PubMed DOI PMC

Bergh P., Kindblom L.G., Gunterberg B., Remotti F., Ryd W., Meis-Kindblom J.M. Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients. Cancer. 2000;88(9):2122–2134. doi: 10.1002/(sici)1097-0142(20000501)88:9<2122::aid-cncr19>3.0.co;2-1. PubMed DOI

Boriani S., Weinstein J.N., Biagini R. Primary bone tumors of the spine. Terminology and surgical staging. Spine. 1997;22(9):1036–1044. doi: 10.1097/00007632-199705010-00020. PubMed DOI

Castiglione M., Conti C., Frondizi D., Cottini E., Cochetti G., Ciampini A., Cellini V., Mearini E. A combined one-staged robot-assisted sacral chordoma resection. World Neurosurg. 2020;141:210–214. doi: 10.1016/j.wneu.2020.06.056. PubMed DOI

Clarke M.J., Dasenbrock H., Bydon A., Sciubba D.M., McGirt M.J., Hsieh P.C., Yassari R., Gokaslan Z.L., Wolinsky J.P. Posterior-only approach for en bloc sacrectomy: clinical outcomes in 36 consecutive patients. Neurosurgery. 2012;71(2):357–364. doi: 10.1227/NEU.0b013e31825d01d4. ; discussion 364. PubMed DOI

Denis F., Davis S., Comfort T. Sacral fractures: an important problem. Retrospective analysis of 236 cases. Clin. Orthop. Relat. Res. 1988;227:67–81. PubMed

Enneking W.F., Spanier S.S., Goodman M.A. A system for the surgical staging of musculoskeletal sarcoma. Clin. Orthop. Relat. Res. 1980;153:106–120. PubMed

Farshad M., Selman F., Burkhard M.D., Müller D., Spirig J.M. Partial sacrectomy with patient-specific osteotomy guides. N Am. Spine Soc. J. 2021;8 doi: 10.1016/j.xnsj.2021.100090. PubMed DOI PMC

Feghali J., Pennington Z., Hung B., Hersh A., Schilling A., Ehresman J., Srivastava S., Cottrill E., Lubelski D., Lo S.F., Sciubba D.M. Sacrectomy for sacral tumors: perioperative outcomes in a large-volume comprehensive cancer center. Spine J. 2021;21(11):1908–1919. doi: 10.1016/j.spinee.2021.05.004. PubMed DOI

Fourney D.R., Rhines L.D., Hentschel S.J., Skibber J.M., Wolinsky J.P., Weber K.L., Suki D., Gallia G.L., Garonzik I., Gokaslan Z.L. En bloc resection of primary sacral tumors: classification of surgical approaches and outcome. J. Neurosurg. Spine. 2005;3(2):111–122. doi: 10.3171/spi.2005.3.2.0111. PubMed DOI

Guo W., Tang X., Zang J., Ji T. One-stage total en bloc sacrectomy: a novel technique and report of 9 cases. Spine. 2013;38(10):E626–E631. doi: 10.1097/BRS.0b013e31828b7045. PubMed DOI

Hsieh P.C., Xu R., Sciubba D.M., McGirt M.J., Nelson C., Witham T.F., Wolinksy J.P., Gokaslan Z.L. Long-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients. Spine. 2009;34(20):2233–2239. doi: 10.1097/BRS.0b013e3181b61b90. PubMed DOI

Huang S., Ji T., Guo W. Biomechanical comparison of a 3D-printed sacrum prosthesis versus rod-screw systems for reconstruction after total sacrectomy: a finite element analysis. Clin. Biomech. 2019;70:203–208. doi: 10.1016/j.clinbiomech.2019.10.019. PubMed DOI

Hugate RR Jr, Dickey I.D., Phimolsarnti R., Yaszemski M.J., Sim F.H. Mechanical effects of partial sacrectomy: when is reconstruction necessary? Clin. Orthop. Relat. Res. 2006;450:82–88. doi: 10.1097/01.blo.0000229331.14029.44. PubMed DOI

Kim J.E., Pang J., Christensen J.M., Coon D., Zadnik P.L., Wolinsky J.P., Gokaslan Z.L., Bydon A., Sciubba D.M., Witham T., Redett R.J., Sacks J.M. Soft-tissue reconstruction after total en bloc sacrectomy. J. Neurosurg. Spine. 2015;22(6):571–581. doi: 10.3171/2014.10.SPINE14114. PubMed DOI

McLoughlin G.S., Sciubba D.M., Suk I., Witham T., Bydon A., Gokaslan Z.L., Wolinsky J.P. En bloc total sacrectomy performed in a single stage through a posterior approach. Neurosurgery. 2008;63(1 Suppl. 1):ONS115–O120. doi: 10.1227/01.neu.0000335025.93026.68. ; discussion ONS120. PubMed DOI

Morales-Codina A.M., Martín-Benlloch J.A. Sacral prosthesis substitution as a system of spinopelvic reconstruction after total sacrectomy: assessment using the finite element method. Internet J. Spine Surg. 2022;8258 doi: 10.14444/8258. PubMed DOI PMC

Murakami H., Kawahara N., Tomita K., Sakamoto J., Oda J. Biomechanical evaluation of reconstructed lumbosacral spine after total sacrectomy. J. Orthop. Sci. 2002;7(6):658–664. doi: 10.1007/s007760200117. PubMed DOI

Reynolds J.J., Khundkar R., Boriani S., Williams R., Rhines L.D., Kawahara N., Wolinsky J.P., Gokaslan Z.L., Varga P.P. Soft tissue and bone defect management in total sacrectomy for primary sacral tumors: a systematic review with expert recommendations. Spine. 2016;41(Suppl. 20):S199–S204. doi: 10.1097/BRS.0000000000001834. PubMed DOI

Roldan H., Perez-Orribo L.F., Plata-Bello J.M., Martin-Malagon A.I., Garcia-Marin V.M. Anterior-only Partial Sacrectomy for en bloc Resection of Locally Advanced Rectal Cancer. Glob. Spine J. 2014;4(4):273–278. doi: 10.1055/s-0034-1375562. PubMed DOI PMC

Sciubba D.M., Petteys R.J., Garces-Ambrossi G.L., Noggle J.C., McGirt M.J., Wolinsky J.P., Witham T.F., Gokaslan Z.L. Diagnosis and management of sacral tumors. J. Neurosurg. Spine. 2009;10(3):244–256. doi: 10.3171/2008.12.SPINE08382. PubMed DOI

Schreiber J.J., Anderson P.A., Hsu W.K. Use of computed tomography for assessing bone mineral density. Neurosurg. Focus. 2014;37(1) doi: 10.3171/2014.5.FOCUS1483. PubMed DOI

Sherman C.E., Rose P.S., Pierce L.L., Yaszemski M.J., Sim F.H. Prospective assessment of patient morbidity from prone sacral positioning. J. Neurosurg. Spine. 2012;16(1):51–56. doi: 10.3171/2011.8.SPINE11560. PubMed DOI

Štulík J., Hoch J., Richtr P., Kříž J., Přikryl P., Kryl J. Hemikorporektomie jako nejvyšší stupeň en bloc resekce sakra [Hemicorporectomy as the Highest Grade of En Bloc Sacrectomy] Acta Chir. Orthop. Traumatol. Cech. 2020;87(1):52–57. Czech. PubMed

Varga P.P., Lazary A. Chordoma of the sacrum: "en bloc" high partial sacrectomy. Eur. Spine J. 2010;19(6):1037–1038. doi: 10.1007/s00586-010-1459-x. PubMed DOI PMC

Varga P.P., Szövérfi Z., Lazary A. Surgical treatment of primary malignant tumors of the sacrum. Neurol. Res. 2014;36(6):577–587. doi: 10.1179/1743132814Y.0000000366. PubMed DOI

Wei R., Guo W., Yang R., Tang X., Yang Y., Ji T., Liang H. Reconstruction of the pelvic ring after total en bloc sacrectomy using a 3D-printed sacral endoprosthesis with re-establishment of spinopelvic stability: a retrospective comparative study. Bone Joint Lett. J. 2019;101-B(7):880–888. doi: 10.1302/0301-620X.101B7.BJJ-2018-1010.R2. PubMed DOI

Wuisman P., Lieshout O., Sugihara S., van Dijk M. Total sacrectomy and reconstruction: oncologic and functional outcome. Clin. Orthop. Relat. Res. 2000;381:192–203. doi: 10.1097/00003086-200012000-00023. PubMed DOI

Yu B.S., Zhuang X.M., Li Z.M., Zheng Z.M., Zhou Z.Y., Zou X.N., Lu W.W. Biomechanical effects of the extent of sacrectomy on the stability of lumbo-iliac reconstruction using iliac screw techniques: what level of sacrectomy requires the bilateral dual iliac screw technique? Clin. Biomech. 2010;25(9):867–872. doi: 10.1016/j.clinbiomech.2010.06.012. PubMed DOI

Zhang W., Liao X.J., Lou Z., Meng R.G., Yu E.D., Fu C.G., Yu D.H. [Transsacral resection for presacral tumors] Zhonghua Wei Chang Wai Ke Za Zhi. 2009;12(5):477–479. Chinese. PubMed

Zhang H.Y., Thongtrangan I., Balabhadra R.S., Murovic J.A., Kim D.H. Surgical techniques for total sacrectomy and spinopelvic reconstruction. Neurosurg. Focus. 2003;15(2) doi: 10.3171/foc.2003.15.2.5. PubMed DOI

Zhu R., Cheng L.M., Yu Y., Zander T., Chen B., Rohlmann A. Comparison of four reconstruction methods after total sacrectomy: a finite element study. Clin. Biomech. 2012;27(8):771–776. doi: 10.1016/j.clinbiomech.2012.05.008. PubMed DOI

Zoccali C., Skoch J., Patel A.S., Walter C.M., Maykowski P., Baaj A.A. Residual neurological function after sacral root resection during en-bloc sacrectomy: a systematic review. Eur. Spine J. 2016;25(12):3925–3931. doi: 10.1007/s00586-016-4450-3. PubMed DOI

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...