PURPOSE: To evaluate the role of an anti-reflux diet in the treatment of patients with chronic cough caused by laryngopharyngeal reflux (LPR). METHODS: This prospective observational study included patients with chronic cough (lasting over 3 months) and laryngopharyngeal reflux (LPR) confirmed by hypopharyngeal-esophageal 24-h multichannel intraluminal impedance-pH monitoring (HEMII-pH), according to Dubai criteria. Participants were categorized based on cough severity using a visual analog scale (VAS) from 1 to 10. A VAS < 5 was considered to indicate mild cough, whereas a VAS ≥ 5 were considered to indicate severe cough. Patients with mild cough were treated by anti-reflux diet only, while those with severe cough received additional treatment with proton pump inhibitors (PPIs) and alginates. After 3 months, treatment effectiveness was evaluated by assessing the reduction in cough severity. RESULTS: In patients with mild cough, anti-reflux diet alone proved to be effective, yielding improvement in 83.3% of cases. Among patients with severe cough, a combination of anti-reflux diet, proton pump inhibitors (PPIs), and alginates proved was effective in 81.8% of cases. CONCLUSION: Diet alone is an effective and sufficient treatment for mild chronic cough in patients with LPR. For patients with severe chronic cough with LPT, combined anti-reflux measures are effective.
- MeSH
- algináty terapeutické užití MeSH
- chronická nemoc MeSH
- chronický kašel MeSH
- dospělí MeSH
- inhibitory protonové pumpy * terapeutické užití MeSH
- kašel * etiologie farmakoterapie MeSH
- laryngofaryngeální reflux * komplikace dietoterapie farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- monitorování jícnového pH MeSH
- prospektivní studie MeSH
- senioři MeSH
- stupeň závažnosti nemoci MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- Klíčová slova
- nintedanib, pirfenidon, voštiny,
- MeSH
- adherence pacienta MeSH
- antifibrotické látky * farmakologie terapeutické užití MeSH
- centra terciární péče MeSH
- hormony kůry nadledvin terapeutické užití MeSH
- idiopatická plicní fibróza * dějiny diagnostické zobrazování farmakoterapie mikrobiologie MeSH
- kašel farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- plicní hypertenze farmakoterapie MeSH
- prognóza MeSH
- sildenafil citrát farmakologie terapeutické užití MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- alergická rýma MeSH
- bronchiální astma MeSH
- kašel * etiologie farmakoterapie MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
Běžná sezónní respirační onemocnění vhodná pro samoléčbu jsou nekomplikovaná onemocnění horních cest dýchacích způsobená běžnými viry. Nejúčinnější léčbou sezónních respiračních onemocnění je komplexní terapie, tedy nejen potlačení symptomů pomocí účinných látek, ale i často opomíjená vhodná režimová opatření.
Common seasonal respiratory disease suitable for self-treatment is an uncomplicated upper respiratory tract disease caused by common viruses. The most effective treatment for seasonal respiratory disease is comprehensive therapy, i.e. not only suppression of symptoms with active agents, but also an often neglected appropriate regimen.
- MeSH
- antiflogistika nesteroidní škodlivé účinky terapeutické užití MeSH
- bolest farmakoterapie MeSH
- fytoterapie MeSH
- kašel farmakoterapie MeSH
- lidé MeSH
- nemoci dýchací soustavy * farmakoterapie MeSH
- nežádoucí účinky léčiv MeSH
- nosní dekongestiva škodlivé účinky terapeutické užití MeSH
- rýma farmakoterapie patologie MeSH
- samoléčba * MeSH
- Check Tag
- lidé MeSH
ETHNOPHARMACOLOGICAL RELEVANCE: Ferns form an important part of the human diet. Young fern fiddleheads are mostly consumed as vegetables, while the rhizomes are often extracted for starch. These edible ferns are also often employed in traditional medicine, where all parts of the plant are used, mostly to prepare extracts. These extracts are applied either externally as lotions and baths or internally as potions, decoctions and teas. Ailments traditionally treated with ferns include coughs, colds, fevers, pain, burns and wounds, asthma, rheumatism, diarrhoea, or skin diseases (eczema, rashes, itching, leprosy). AIM OF THE REVIEW: This review aims to compile the worldwide knowledge on the traditional medicinal uses of edible fern species correlating to reported biological activities and isolated bioactive compounds. MATERIALS AND METHODS: The articles and books published on edible fern species were searched through the online databases Web of Science, Pubmed and Google Scholar, with critical evaluation of the hits. The time period up to the end of 2022 was included. RESULTS: First, the edible fern species were identified based on the literature data. A total of 90 fern species were identified that are eaten around the world and are also used in traditional medicine. Ailments treated are often associated with inflammation or bacterial infection. However, only the most common and well-known fern species, were investigated for their biological activity. The most studied species are Blechnum orientale L., Cibotium barometz (L.) J. Sm., Diplazium esculentum (Retz.) Sw., Marsilea minuta L., Osmunda japonica Thunb., Polypodium vulgare L., and Stenochlaena palustris (Burm.) Bedd. Most of the fern extracts have been studied for their antioxidant, anti-inflammatory and antimicrobial activities. Not surprisingly, antioxidant capacity has been the most studied, with results reported for 28 edible fern species. Ferns have been found to be very rich sources of flavonoids, polyphenols, polyunsaturated fatty acids, carotenoids, terpenoids and steroids and most of these compounds are remarkable free radical scavengers responsible for the outstanding antioxidant capacity of fern extracts. As far as clinical trials are concerned, extracts from only three edible fern species have been evaluated. CONCLUSIONS: The extracts of edible fern species exert antioxidant anti-inflammatory and related biological activities, which is consistent with their traditional medicinal use in the treatment of wounds, burns, colds, coughs, skin diseases and intestinal diseases. However, studies to prove pharmacological activities are scarce, and require chemical-biological standardization. Furthermore, correct botanical classification needs to be included in publications to simplify data acquisition. Finally, more in-depth phytochemical studies, allowing the linking of traditional use to pharmacological relevance are needed to be done in a standardized way.
- MeSH
- antiflogistika farmakologie terapeutické užití MeSH
- antioxidancia MeSH
- etnofarmakologie MeSH
- fytonutrienty farmakologie terapeutické užití MeSH
- fytoterapie MeSH
- kapradiny * MeSH
- kašel farmakoterapie MeSH
- kožní nemoci * farmakoterapie MeSH
- lidé MeSH
- nachlazení * farmakoterapie MeSH
- popálení * farmakoterapie MeSH
- rostlinné extrakty farmakologie terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Cough is one of the most important airway defensive reflexes aimed at removing foreign particles or endogenously produced materials from the airways and provides protection against aspiration. Generally considered, cough is a vital physiological defensive mechanism for lung health. However, in case of cough dysregulation this reflex can become pathological and leads to an adverse influence on daily life. Therefore, it is necessary to effectively evaluate the severity of cough for its diagnosis and treatment. There are subjective and objective methods for assessing cough. These methods should help describe the heterogeneity of cough phenotypes and may establish better treatment by monitoring response to nonpharmacological or pharmacological therapies. It is important to keep in mind that the clinical assessment of cough should include both tools that measure the amount and severity of the cough. The importance of a combined subjective and objective evaluation for a comprehensive assessment of cough has been advocated in the guidelines of the European Respiratory Society on cough evaluation. This review article provides an overview of subjective and objective methods for assessing and monitoring cough in children and adults comparing to animal models. Key words Cough frequency; Cough intensity; Cough reflex sensitivity; Cough monitors; Cough assessment.
Běžná sezónní respirační onemocnění vhodná pro samoléčbu jsou nekomplikovaná onemocnění horních cest dýchacích způsobená běžnými viry. Nejúčinnější léčbou sezónních respiračních onemocnění je komplexní terapie, tedy nejen potlačení symptomů pomocí účinných látek, ale i často opomíjená vhodná režimová opatření.
Common seasonal respiratory disease suitable for self-treatment is an uncomplicated upper respiratory tract disease caused by common viruses. The most effective treatment for seasonal respiratory disease is comprehensive therapy, i.e. not only suppression of symptoms with active agents, but also an often neglected appropriate regimen.
- MeSH
- antiflogistika nesteroidní škodlivé účinky terapeutické užití MeSH
- bolest farmakoterapie MeSH
- fytoterapie MeSH
- kašel farmakoterapie MeSH
- lidé MeSH
- nemoci dýchací soustavy * farmakoterapie MeSH
- nežádoucí účinky léčiv MeSH
- nosní dekongestiva škodlivé účinky terapeutické užití MeSH
- rýma farmakoterapie patologie MeSH
- samoléčba * MeSH
- Check Tag
- lidé MeSH
- MeSH
- antifibrinolytika terapeutické užití MeSH
- anxiolytika terapeutické užití MeSH
- dítě MeSH
- dyspnoe etiologie farmakoterapie psychologie MeSH
- hemoptýza etiologie terapie MeSH
- kašel farmakoterapie MeSH
- lidé MeSH
- opioidní analgetika terapeutické užití MeSH
- oxygenoterapie metody MeSH
- paliativní péče * metody MeSH
- polohování pacienta MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- přehledy MeSH
Various medicinal plants find their use in cough treatment, based on traditions and long-term experience. Pharmacological principles of their action, however, are much less known. Herbal drugs usually contain a mixture of potentially active compounds, which can manifest diverse effects. Expectorant or antitussive effects, which can be accompanied by others, such as anti-inflammatory or antibacterial, are probably the most important in the treatment of coughs. The aim of this review is to summarize the current state of knowledge of the effects of medicinal plants or their constituents on cough, based on reliable pharmacological studies. First, a comprehensive description of each effect is provided in order to explain the possible mechanism of action in detail. Next, the results related to individual plants and substances are summarized and critically discussed based on pharmacological in vivo and in vitro investigation.
- MeSH
- antitusika farmakologie klasifikace terapeutické užití MeSH
- kašel * etiologie farmakoterapie MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
