Článek zmiňuje výsledky šetření výskytu poranění kůže u novorozenců, které proběhlo v roce 2023 v perinatologických centrech a v dalších třech zdravotnických zařízeních v České republice. Výsledky porovnává s podobným šetřením, které proběhlo v roce 2020 a 2022.
The article mentions the results of a survey of the occurrence of skin injuries in newborns, which took place in 2023 in perinatological centers and in three other medical facilities in the Czech Republic. It compares the results with a similar survey that took place in 2020 and 2022. The results of the survey in 2023 showed that the total number of skin injuries in newborns in monitored healthcare facilities gradually decreased from the original 537 in 2020 to 428 in 2022 to 367 in 2023. The most common type of skin injury also changed, namely extravasation/infiltration in 2020 to erosions/excoriations in 2022 and 2023. Of the procedures used, the wet wound healing method prevailed in 2022 and 2023 over the classic method, which was the most used in 2020.
Cieľom predkladaného príspevku je zvýšiť povedomie o výskyte kožných poranení spojených s používaním adhezívnych materiálov pri poskytovaní zdravotnej starostlivosti. Snahou je podporiť zmenu v kultúre prístupu, aby prevencia poranenia kože súvisiaceho s lekárskym lepidlom sa stala neoddeliteľnou súčasťou komplexnej starostlivosti o pacienta. Preventívne opatrenia sú nevyhnutné pre minimalizáciu rizík a zabezpečenie optimálnej starostlivosti. Dodržiavanie správnych postupov môže výrazne znížiť riziko komplikácii a podporiť procesy vedúce k uzdraveniu pacienta. Potreba vzdelávania o tejto forme poškodenia kože je jednou z rozhodujúcich tém v starostlivosti o pokožku a manažmente rán.
The aim of the present paper is to raise awareness of the incidence of skin injuries associated with the use of adhesive materials in the delivery of healthcare. It seeks to promote a culture change in approach so that prevention of medical adhesive-related skin injury becomes an integral part of comprehensive patient care. Preventive measures are essential to minimize risks and ensure optimal care. Adherence to proper procedures can significantly reduce the risk of complications and promote processes leading to patient healing. The need for education about this form of skin damage is one of the critical topics in skin care and wound management.
- Klíčová slova
- MARSI syndrom,
- MeSH
- adheziva * škodlivé účinky MeSH
- kůže * zranění MeSH
- lidé MeSH
- rány a poranění chemicky indukované prevence a kontrola MeSH
- rizikové faktory MeSH
- Check Tag
- lidé MeSH
- Klíčová slova
- MASD- Moisture-associated skin damage,
- MeSH
- hojení ran MeSH
- inkontinence moči MeSH
- kůže zranění MeSH
- péče o kůži MeSH
- plenková dermatitida etiologie farmakoterapie ošetřování terapie MeSH
- rány a poranění etiologie ošetřování terapie MeSH
- vlhkost MeSH
- výsledek terapie MeSH
- Publikační typ
- kazuistiky MeSH
- NLK Obory
- hygiena
- MeSH
- hojení ran MeSH
- kůže zranění MeSH
- nekróza MeSH
- novorozenci extrémně nezralí MeSH
- obvazy hydrokoloidní MeSH
- výsledek terapie MeSH
- Publikační typ
- kazuistiky MeSH
The purpose of this study was to evaluate the impact of 1% and 2% topical nifedipine ointments on TGF-β and the acceleration of facial skin wound healing in rabbits. Nifedipine ointments of 1% and 2% were prepared. Fifty healthy male rabbits were involved and distributed into two groups according to the study period: group A (7 days) and group B (14 days). Each group was subdivided into five groups (5 rabbits/group): Group I (Normal): rabbits did not undergo a surgical procedure and did not receive treatment; group II (negative control): rabbits had surgical wounds without treatment; group III (positive control): rabbits had surgical wounds with white petroleum treatment; group IV(nifedipine 1%): rabbits had surgical wounds with nifedipine 1% ointment treatment; and group V(nifedipine 2%): rabbits had surgical wounds with nifedipine 2% ointment treatment. Following euthanasia, blood samples (5 ml) were collected from all animals for TGF-β analysis using an ELISA kit. The TGF-β level in NFD 1% group was significantly higher on the 7th and14th day of the study associated with a higher rate of wound closure in comparison to other groups. Conclusions: Nifedipine 1% ointment has beneficial value for improving wound healing, while nifedipine NFD 2% has no such effect.
Growth hormone (GH) the most abundant hormone secreted by the anterior pituitary gland could have a role with other growth factors in wound healing because they can help in the physiological wound healing process.Aims: To investigate the effects of GH on facial skin wound healing in rabbits and to evaluate its effect on "insulin-like growth factor (IGF-1)" and "transforming growth factor- β (TGF-β)" in serum. Material and Method: Thirty healthy male rabbits included in this study were classified into two groups according to the day of euthanization 7 and 14 days of study, each group was subdivided into three groups; negative control group, positive control group, and treatment group, full-thickness circle 1 cm wounds were excised in the skin of the forehead for each rabbit without any medication.3-(treated group) full-thickness circle 1 cm wounds will excise in the skin of the forehead for each rabbit, 0.1ml [contain 1.2mg /3.6 IU] of growth hormone injected subcutaneously around the incision, the injection process is every other day.Result: showed a highly significant difference among all study groups in serum TGF-β (ng/L) and IGF (ng/ml) during the first and second weeks. the serum TGF-β at the end of the first and second weeks showed a significant elevation in the treatment group when compared to the other study groups. There is no significant difference between the two control groups. The serum IGF at the end of the first and second weeks showed a significant difference in IGF levels among all study groups.Conclusions: Topical GH has a role in skin wound healing since it can increase the serum level of TGF-β. GH also causes a decrease in serum IGF. Topical GH may have a positive impact on skin wound healing.
- MeSH
- aplikace lokální MeSH
- experimenty na zvířatech MeSH
- hojení ran * fyziologie účinky léků MeSH
- injekce subkutánní MeSH
- insulinu podobný růstový faktor I analýza fyziologie metabolismus MeSH
- králíci MeSH
- kůže zranění MeSH
- obličej MeSH
- růstový hormon aplikace a dávkování terapeutické užití MeSH
- studie případů a kontrol MeSH
- transformující růstový faktor beta analýza fyziologie metabolismus MeSH
- Check Tag
- králíci MeSH
This article describes the characterization and application of collagenase-based chitosan nanofiber membranes with rat burns. Electrospun chitosan nanofibers were functionalized with clostridial collagenase using carbodiimide chemistry. The immobilized collagenase was characterized by enzyme activity, kinetic constants, and dry storage stability measurements using a Pz-peptide substrate. The apparent kinetic constants KM and Vmax of immobilized collagenase showed a high affinity for the peptide substrate compared to the free enzyme. Drying of chitosan membranes with immobilized collagenase ensured 98 % stability of enzyme activity after rehydration. The effect of collagenase immobilized on chitosan nanofibers on the burn of the rat model was compared with a control treatment with chitosan nanofibers. The healing of the wound with both materials was terminated after 30 days at the same time, although the collagenase wound healed more rapidly during healing. The scar area size after the application of collagenase-containing chitosan nanofiber membranes was 31.6 % smaller than when only chitosan nanofibers were used.
- MeSH
- chitosan terapeutické užití MeSH
- Clostridium histolyticum MeSH
- enzymy imobilizované MeSH
- hojení ran * účinky léků MeSH
- krysa rodu rattus MeSH
- kůže zranění MeSH
- mikrobiální kolagenasa * metabolismus terapeutické užití MeSH
- nanovlákna terapeutické užití MeSH
- pilotní projekty MeSH
- rány a poranění farmakoterapie patologie MeSH
- stabilita enzymů MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
The primary function of the skin is that of a physical barrier against the environment and diverse pathogens; therefore, its integrity is essential for survival. Skin regeneration depends on multiple stem cell compartments within the epidermis, which, despite their different transcriptional and proliferative capacity, as well as different anatomical location, fall under the general term of skin stem cells (SSCs). Skin wounds can normally heal without problem; however, some diseases or extensive damage may delay or prevent healing. Non-healing wounds represent a serious and life-threatening scenario that may require advanced therapeutic strategies. In this regard, increased focus has been directed at SSCs and their role in wound healing, although emerging therapeutical approaches are considering the use of other stem cells instead, such as mesenchymal stem cells (MSCs). Given its extensive and broad nature, this review supplies newcomers with an introduction to SSCs, wound healing, and therapeutic strategies for skin regeneration, thus familiarizing the reader with the subject in preparation for future in depth reading.
