This two-volume set investigates the interaction of organic compounds with various forms of life, including macromolecules, enzymes, and organelles. It provides an introduction to the Hammett equation and its applications, as well as a discussion of the design of bioactive compounds. Volume 2 includes extensive tables of approximately 17,000 partition coefficients from octanol-water and a comprehensive listing of electronic and steric parameters in the design and study of bioactive organic compounds.