Práce se zabývá genetickými polymorfismy v genu pro angiotenzinogen ve skupině psoriáz (136nemocných) a zdravých probandů (141 osob). Byl analyzován polymorfismus M235T v genu proangiotenzinogen a polymorfismus A(-6)G AGT. Statisticky byly hodnoceny alelické frekvence jednot-livých polymorfismů, test pro Hardyho-Weinbergovo ekvilibrium a síla vazby mezi oběma polymor-fismy.Vyšetřované polymorfismy jsou ve vazbě jak u kontrolních, tak u psoriatických osob, přičemž sílavazby je větší u psoriatiků a nerozlišitelná mezi muži a ženami. U kontrol i nemocných se spolučastěji vyskytují alely T s A a M s G.

The study was focused on an association between psoriasis and genetic variants of angiotensino-gen which can participate as an acute phase protein in etiopathogenesis of psoriasis. Two polymor-phisms of angiotensinogen [M235T ATG and A(-6)G ATG] gene were investigated in 136 Caucasianpatients with psoriasis and 141 healthy subjects with negative familiar history of psoriasis. Thepolymorphisms were detected by polymerase chain reaction-based methods and restriction enzymeanalysis. No differences were found in the allelic frequencies of the single polymorphisms betweenpatients and control subjects. Both in psoriatic and control groups, the observed numbers ofgenotype carriers of single determined polymorphisms were not different of calculated numbers andwere in agreement with Hardy-Weinberg equilibrium. The tight linkage dysequilibrium was foundfor double genotypes, both in patient and control groups. Concurrence of double genotypes of twoangiotensinogen gene polymorphisms was found to be different between patient and control groups(P = 0.001).

1 dermatovenerologická klinika ve FN u sv Anny LF MU Brno

Association of psoriasis with angiotensinogen gene polymorphisms

Asociace psoriázy se dvěma genetickými polymorfismy v genu pro angiotenzinogen = Association of psoriasis with angiotensinogen gene polymorphisms /

Association of psoriasis with angiotensinogen gene polymorphisms /

Lit: 15

Souhrn: eng