-
Something wrong with this record ?
Adenosine potentiates stimulatory effects on granulocyte-macrophage hematopoietic progenitor cells in vitro of IL-3 and SCF, but not those of G-CSF, GM-CSF and IL-11
A. Hofer, A. Vacek, M. Pospíšil, L. Weiterová, J. Holá, D. Štreitová, V. Znojil
Language English Country Czech Republic
Document type Comparative Study
NLK
Directory of Open Access Journals
from 1991
Free Medical Journals
from 1998
ProQuest Central
from 2005-01-01
Medline Complete (EBSCOhost)
from 2006-01-01
Nursing & Allied Health Database (ProQuest)
from 2005-01-01
Health & Medicine (ProQuest)
from 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1998
- MeSH
- Adenosine pharmacokinetics MeSH
- Cytokines pharmacokinetics chemistry MeSH
- Granulocyte-Macrophage Colony-Stimulating Factor pharmacokinetics physiology chemistry MeSH
- Hematopoietic Cell Growth Factors pharmacokinetics MeSH
- Financing, Government MeSH
- Interleukins pharmacokinetics physiology chemistry MeSH
- Data Interpretation, Statistical MeSH
- Mice, Inbred C57BL MeSH
- Mice, Inbred CBA MeSH
- Stem Cell Factor pharmacokinetics physiology chemistry MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Comparative Study MeSH
The aim of the studies was to ascertain if adenosine is able to co-operate with selected hematopoietic growth factors and cytokines, namely with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), stem cell factor (SCF), interleukin-3 (IL-3), and interleukin-11 (IL-11), in inducing the growth of colonies from hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) from normal bone marrow cells in vitro. Adenosine was found not to produce any colonies when present in the cultures as the only potential stimulator. All the tested cytokines and growth factors were observed to induce the growth of distinct numbers of GM-CFC colonies, with the exception of IL-11. When suboptimal concentrations of the evaluated cytokines and growth factors were tested in the cultures in which various concentrations of adenosine were concomitantly present, mutually potentiating effects were found in the case of IL-3 and SCF. These results confirm the role of adenosine in regulation of granulopoiesis and predict IL-3 and SCF as candidates for further in vivo studies of their combined administration with adenosine.
Grant č. 50040507 AVOZ -- Grant č. 305/06/0015
Bibliography, etc.Lit.: 22
- 000
- 03545naa 2200505 a 4500
- 001
- bmc07500520
- 003
- CZ-PrNML
- 005
- 20111210120855.0
- 008
- 070724s2006 xr e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Hofer, Michal $7 xx0074123
- 245 10
- $a Adenosine potentiates stimulatory effects on granulocyte-macrophage hematopoietic progenitor cells in vitro of IL-3 and SCF, but not those of G-CSF, GM-CSF and IL-11 / $c A. Hofer, A. Vacek, M. Pospíšil, L. Weiterová, J. Holá, D. Štreitová, V. Znojil
- 314 __
- $a Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno
- 500 __
- $a Grant č. 50040507 AVOZ -- Grant č. 305/06/0015
- 504 __
- $a Lit.: 22
- 520 9_
- $a The aim of the studies was to ascertain if adenosine is able to co-operate with selected hematopoietic growth factors and cytokines, namely with granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), stem cell factor (SCF), interleukin-3 (IL-3), and interleukin-11 (IL-11), in inducing the growth of colonies from hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) from normal bone marrow cells in vitro. Adenosine was found not to produce any colonies when present in the cultures as the only potential stimulator. All the tested cytokines and growth factors were observed to induce the growth of distinct numbers of GM-CFC colonies, with the exception of IL-11. When suboptimal concentrations of the evaluated cytokines and growth factors were tested in the cultures in which various concentrations of adenosine were concomitantly present, mutually potentiating effects were found in the case of IL-3 and SCF. These results confirm the role of adenosine in regulation of granulopoiesis and predict IL-3 and SCF as candidates for further in vivo studies of their combined administration with adenosine.
- 650 _2
- $a faktory růstu hematopoetických buněk $x farmakokinetika $7 D016298
- 650 _2
- $a adenosin $x farmakokinetika $7 D000241
- 650 _2
- $a cytokiny $x farmakokinetika $x chemie $7 D016207
- 650 _2
- $a faktor stimulující granulocyto-makrofágové kolonie $x farmakokinetika $x fyziologie $x chemie $7 D016178
- 650 _2
- $a interleukiny $x farmakokinetika $x fyziologie $x chemie $7 D007378
- 650 _2
- $a růstový faktor kmenových buněk $x farmakokinetika $x fyziologie $x chemie $7 D019089
- 650 _2
- $a interpretace statistických dat $7 D003627
- 650 _2
- $a myši inbrední CBA $7 D008808
- 650 _2
- $a myši inbrední C57BL $7 D008810
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a financování vládou $7 D005380
- 655 _2
- $a srovnávací studie $7 D003160
- 700 1_
- $a Pospíšil, Milan, $d 1931- $7 jk01100712
- 700 1_
- $a Weiterová, Lenka $7 xx0075192
- 700 1_
- $a Holá, Jiřina $7 xx0074137
- 700 1_
- $a Štreitová, Denisa, $d 1976-
- 700 1_
- $a Znojil, Vladimír, $d 1941-2008 $7 ola2003204904
- 700 1_
- $a Vacek, Antonín, $d 1929-2009 $7 jk01140948
- 773 0_
- $w MED00003824 $t Physiological research $g Roč. 55, č. 5 (2006), s. 591-596 $x 0862-8408
- 856 41
- $u https://www.biomed.cas.cz/physiolres/pdf/55/55_591.pdf $y plný text volně přístupný
- 910 __
- $y 1 $a ABA008 $b A 4120 $c 266
- 990 __
- $a 20070723155916 $b ABA008
- 991 __
- $a 20100127100423 $b ABA008
- 999 __
- $a ok $b bmc $g 616134 $s 468566
- BAS __
- $a 3
- BMC __
- $a 2006 $b 55 $c 5 $d 591-596 $i 0862-8408 $m Physiological research $x MED00003824
- LZP __
- $a 2007-5/mkal