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Liver injury and pancytopenia as initial symptoms of acute lymphoblastic leukaemia : a case report [Hepatocelulární poškození a pancystopenie jako prvotní příznaky akutní lymfoblastické leukemie : kazuistika]
Anna Dziurkowska-Marek, Marek Hartleb, Jacek Pająk, Slawomira Krzemień, Hubert Bołdys, Andrzej Nowak, Jerzy Hołowiecki
Jazyk angličtina Země Česko
Typ dokumentu kazuistiky
- MeSH
- akutní lymfatická leukemie diagnóza komplikace terapie MeSH
- hemoragické poruchy etiologie terapie MeSH
- hepatitida diagnóza etiologie MeSH
- lidé MeSH
- pancytopenie etiologie terapie MeSH
- protokoly protinádorové kombinované chemoterapie terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
Haematological malignancies commonly involve the liver, however, they rarely cause clinically significant hepatic disease. Hepatic involvement as the prodromal manifestation of acute leukaemia is exceptional. We describe a 54-year-old female who developed recurrent, symptomatic hepatitis and thrombocytopenia as initial features of acute lymphoblastic leukaemia. Transjugular hepatic biopsy revealed porto-sinusoidal infiltration with blast-cells. At immunohistochemistry the infiltrating cells shared the phenotypic characteristics of the medullary infiltrate. The patient was treated with a PALG 4-2002 chemotherapy regimen, which led to partial remission of haematological disease and normalization of hepatic laboratory tests.
Hepatocelulární poškození a pancystopenie jako prvotní příznaky akutní lymfoblastické leukemie : kazuistika
Lit.: 10
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- $a Dziurkowska-Marek, Anna
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- $a Liver injury and pancytopenia as initial symptoms of acute lymphoblastic leukaemia : $b a case report / $c Anna Dziurkowska-Marek, Marek Hartleb, Jacek Pająk, Slawomira Krzemień, Hubert Bołdys, Andrzej Nowak, Jerzy Hołowiecki
- 246 11
- $a Hepatocelulární poškození a pancystopenie jako prvotní příznaky akutní lymfoblastické leukemie : $b kazuistika
- 314 __
- $a Department of Gastroenterology, Silesian Medical School, Katowice
- 504 __
- $a Lit.: 10
- 520 9_
- $a Haematological malignancies commonly involve the liver, however, they rarely cause clinically significant hepatic disease. Hepatic involvement as the prodromal manifestation of acute leukaemia is exceptional. We describe a 54-year-old female who developed recurrent, symptomatic hepatitis and thrombocytopenia as initial features of acute lymphoblastic leukaemia. Transjugular hepatic biopsy revealed porto-sinusoidal infiltration with blast-cells. At immunohistochemistry the infiltrating cells shared the phenotypic characteristics of the medullary infiltrate. The patient was treated with a PALG 4-2002 chemotherapy regimen, which led to partial remission of haematological disease and normalization of hepatic laboratory tests.
- 650 _2
- $a akutní lymfatická leukemie $x diagnóza $x komplikace $x terapie $7 D054198
- 650 _2
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- 650 _2
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- 650 _2
- $a protokoly protinádorové kombinované chemoterapie $x terapeutické užití $7 D000971
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- $a Nowak, Andrzej
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- $a Hołowiecki, Jerzy
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- $w MED00013921 $t Folia gastroenterologica et hepatologica $g Roč. 4, č. 2 (2006), s. 67-71 $x 1214-4088
- 856 41
- $u http://www.pro-folia.org/files/1/2006/2/dziurkowska.pdf $y plný text volně přístupný
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- $a 2007-9/mkmd
