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Proteomic analysis of antibody response in a case of laboratory-acquired infection with Francisella tularensis subsp. tularensis
Silvie Janovská, Ivona Pávková, Markéta Reichelová, M. Hubálek, Jiří Stulík, Aleš Macela
Jazyk angličtina Země Česko
- MeSH
- 2D gelová elektroforéza metody využití MeSH
- finanční podpora výzkumu jako téma MeSH
- Francisella tularensis imunologie patogenita účinky léků MeSH
- imunoblotting metody využití MeSH
- laboratorní infekce diagnóza farmakoterapie MeSH
- lidé MeSH
- protilátky bakteriální izolace a purifikace MeSH
- spektrální analýza metody využití MeSH
- Check Tag
- lidé MeSH
Immunoproteomic analysis was applied to study the immunoreactivity of serum samples collected at different time points from a laboratory assistant accidentally infected with highly virulent strain of Francisella tularensis subsp. tularensis. Immunoblotting showed that the spectrum of F. tularensis antigens recognized specifically by immune sera remained with the exception for 1 antigen stable for up to 16 years after infection. Using immunoproteomics approach 10 immunoreactive antigens were successfully identified. Several new immunogenic F. tularensis proteins were described for the first time.
Grant č. MO0FVZ 0000501 Ministerstvo obrany České republiky
Bibliografie atd.Lit.: 21
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- $a Immunoproteomic analysis was applied to study the immunoreactivity of serum samples collected at different time points from a laboratory assistant accidentally infected with highly virulent strain of Francisella tularensis subsp. tularensis. Immunoblotting showed that the spectrum of F. tularensis antigens recognized specifically by immune sera remained with the exception for 1 antigen stable for up to 16 years after infection. Using immunoproteomics approach 10 immunoreactive antigens were successfully identified. Several new immunogenic F. tularensis proteins were described for the first time.
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