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Phenylhydrazine haematotoxicity
Josef Berger
Language English Country Czech Republic
NLK
Free Medical Journals
from 2003 to 2013
Freely Accessible Science Journals
from 2003 to 2013
ROAD: Directory of Open Access Scholarly Resources
from 2002
- MeSH
- Gene Expression immunology radiation effects MeSH
- Phenylhydrazines pharmacokinetics adverse effects therapeutic use MeSH
- Anemia, Hemolytic etiology blood MeSH
- Membrane Proteins physiology MeSH
- Lipid Peroxidation drug effects radiation effects MeSH
- Reactive Oxygen Species adverse effects MeSH
- Spectrin chemistry MeSH
- Mutagenicity Tests utilization MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
Phenylhydrazine and its derivatives were first given a medical application at the end of the 19th century but with with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-induced haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This compound can modulate immune reactions.
References provided by Crossref.org
Lit.: 61
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- $a 10.32725/jab.2007.017 $2 doi
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- $a Berger, Josef, $d 1949- $7 jn19990010050
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- $a Phenylhydrazine haematotoxicity / $c Josef Berger
- 314 __
- $a Faculty of Health and Social Studies, University of South Bohemia, České Budějovice
- 504 __
- $a Lit.: 61
- 520 9_
- $a Phenylhydrazine and its derivatives were first given a medical application at the end of the 19th century but with with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-induced haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This compound can modulate immune reactions.
- 650 _2
- $a fenylhydraziny $x farmakokinetika $x škodlivé účinky $x terapeutické užití $7 D010659
- 650 _2
- $a reaktivní formy kyslíku $x škodlivé účinky $7 D017382
- 650 _2
- $a membránové proteiny $x fyziologie $7 D008565
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- $a spektrin $x chemie $7 D013049
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- $a hemolytické anemie $x etiologie $x krev $7 D000743
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- $a testy genotoxicity $x využití $7 D009152
- 650 _2
- $a peroxidace lipidů $x účinky léků $x účinky záření $7 D015227
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- $a exprese genu $x imunologie $x účinky záření $7 D015870
- 650 _2
- $a zvířata $7 D000818
- 773 0_
- $w MED00012667 $t Journal of applied biomedicine $g Roč. 5, č. 3 (2007), s. 125-130 $x 1214-021X
- 856 41
- $u https://jab.zsf.jcu.cz/pdfs/jab/2007/03/02.pdf $y plný text volně přístupný
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- LZP __
- $a 2008-2/ipal
