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Phenylhydrazine haematotoxicity
Josef Berger
Jazyk angličtina Země Česko
NLK
Free Medical Journals
od 2003 do 2013
Freely Accessible Science Journals
od 2003 do 2013
ROAD: Directory of Open Access Scholarly Resources
od 2002
- MeSH
- exprese genu imunologie účinky záření MeSH
- fenylhydraziny farmakokinetika škodlivé účinky terapeutické užití MeSH
- hemolytické anemie etiologie krev MeSH
- membránové proteiny fyziologie MeSH
- peroxidace lipidů účinky léků účinky záření MeSH
- reaktivní formy kyslíku škodlivé účinky MeSH
- spektrin chemie MeSH
- testy genotoxicity využití MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
Phenylhydrazine and its derivatives were first given a medical application at the end of the 19th century but with with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-induced haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This compound can modulate immune reactions.
Citace poskytuje Crossref.org
Lit.: 61
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- $a 10.32725/jab.2007.017 $2 doi
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- $a Faculty of Health and Social Studies, University of South Bohemia, České Budějovice
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- $a Lit.: 61
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- $a Phenylhydrazine and its derivatives were first given a medical application at the end of the 19th century but with with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-induced haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This compound can modulate immune reactions.
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- $a membránové proteiny $x fyziologie $7 D008565
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- $a zvířata $7 D000818
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- $w MED00012667 $t Journal of applied biomedicine $g Roč. 5, č. 3 (2007), s. 125-130 $x 1214-021X
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