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A new linker for solid-phase synthesis of oligonucleotides with terminal phosphate group
Ondřej Pačes, Zdeněk Točík, Ivan Rosenberg
Collection of Czechoslovak Chemical Communications.
2008 ;
73 (1) :
32-43.
Jazyk angličtina Země Česko
Perzistentní odkaz
https://www.medvik.cz/link/bmc07505540
Online
NLK
ProQuest Central
od 2005-01-01 do 2011
- MeSH
- financování organizované MeSH
- oligonukleotidy chemická syntéza MeSH
- vztahy mezi strukturou a aktivitou MeSH
Synthesis of a novel cyanoethyl-type linker suitable for the solid-phase synthesis of oligodeoxynucleotides possessing terminal 3'-phosphate group is described. Since the linker is a 2-substituted 2-cyanoethanol, the release of the synthesized oligonucleotide from the solid support is accomplished by ß-elimination in the ammonia deprotection step.
Bibliografie atd.
Lit.: 23
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