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TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death
Vaculová A, Hofmanová J, Andera L, Kozubík A.
Language English Country Ireland
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Adenocarcinoma pathology MeSH
- Apoptosis genetics MeSH
- Cell Adhesion MeSH
- Financing, Organized MeSH
- Docosahexaenoic Acids pharmacology MeSH
- Drug Interactions MeSH
- Humans MeSH
- Membrane Glycoproteins physiology MeSH
- Tumor Cells, Cultured MeSH
- Colonic Neoplasms pathology MeSH
- Apoptosis Regulatory Proteins MeSH
- Gene Expression Regulation, Neoplastic drug effects MeSH
- Tumor Necrosis Factor-alpha physiology MeSH
- Cell Survival MeSH
- Check Tag
- Humans MeSH
The resistance of some cancer cells to TRAIL-induced apoptosis is a major obstacle in successful clinical application of this cytokine. Combination treatment with agents capable of sensitising the cells to TRAIL effects is beneficial for new cancer treatment strategies. Docosahexaenoic acid (DHA) is under intense investigation for its ability to affect cancer cell growth and apoptosis. We demonstrated a modulation of TRAIL-induced apoptosis of HT-29 human colon cancer cells by DHA on the molecular (pro-caspase-3, -8, Bid, PARP cleavage) and cellular (cell viability and adhesion) level. To conclude, TRAIL and DHA were shown to cooperate in the induction of colon cancer cell apoptosis.
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- $a Laboratory of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 612 65 Brno, Czech Republic.
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- $a The resistance of some cancer cells to TRAIL-induced apoptosis is a major obstacle in successful clinical application of this cytokine. Combination treatment with agents capable of sensitising the cells to TRAIL effects is beneficial for new cancer treatment strategies. Docosahexaenoic acid (DHA) is under intense investigation for its ability to affect cancer cell growth and apoptosis. We demonstrated a modulation of TRAIL-induced apoptosis of HT-29 human colon cancer cells by DHA on the molecular (pro-caspase-3, -8, Bid, PARP cleavage) and cellular (cell viability and adhesion) level. To conclude, TRAIL and DHA were shown to cooperate in the induction of colon cancer cell apoptosis.
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