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Association of MHC class I chain related gene-A microsatellite polymorphism with the susceptibility to T1DM and LADA in Czech adult patients
Novota P, Kolostova K, Pinterova D, Novak J, Weber P, Treslova L, Kovar J, Andel M, Cerna M.
Language English Country Great Britain
Grant support
NB7432
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
Medline Complete (EBSCOhost)
from 2005-02-01 to 1 year ago
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
- MeSH
- Diabetes Mellitus, Type 1 genetics MeSH
- Adult MeSH
- Financing, Organized MeSH
- Genetic Predisposition to Disease genetics MeSH
- Humans MeSH
- Histocompatibility Antigens Class I genetics MeSH
- Microsatellite Repeats genetics MeSH
- Polymorphism, Genetic genetics MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Geographicals
- Czech Republic MeSH
The results in this study suggest that microsatellite polymorphism within the transmembrane region of MIC-A gene is associated with genetic susceptibility to adult-onset of type 1 diabetes mellitus (T1DM), MIC-A5.1 allele, corrected P = 0.001, whereas it is not associated with latent autoimmune diabetes in adults (LADA) in Czech population. According to our findings, we can hypothesize that adult-onset T1DM and LADA may have partly different immunogenetic aetiopathogenesis
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- $a Department of Cell and Molecular Biology, the 3rd Faculty of Medicine, Charles University, Ruská 87, 100 21 Prague 10, Czech Republic.
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- $a The results in this study suggest that microsatellite polymorphism within the transmembrane region of MIC-A gene is associated with genetic susceptibility to adult-onset of type 1 diabetes mellitus (T1DM), MIC-A5.1 allele, corrected P = 0.001, whereas it is not associated with latent autoimmune diabetes in adults (LADA) in Czech population. According to our findings, we can hypothesize that adult-onset T1DM and LADA may have partly different immunogenetic aetiopathogenesis
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