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Downregulation of myc promoter-binding protein 1 (MBP-1) in growth-arrested malignant B cells

Daniel Tvrdík, Pavel Dundr, Ctibor Povýšil, Petr Přikryl, Štěpánka Melčáková, Martina Planková

. 2007 ; 53 (6) : 207-215.

Language English Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc07507002

Normal human B lymphocytes are sensitive to the growth-inhibitory action of TGF-beta1 whereas malignant B lymphoma cells are mostly resistant to TGF-beta1 effects. We have shown in our previous work that, TGF-beta1 treatment resulted in significant growth inhibition of the DoHH2 cell line. In the present study we showed that TGF-beta1-induced growth arrest was associated with notable downregulation of the myc-binding protein-1 (MBP-1). Moreover, our results indicated that c-Myc overexpression in TGF-beta1-arrested malignant B cells is mediated by binding of MBP-1, as a transcription repressor, to the (+118/+153) element of the promoter region of the myc gene.

Bibliography, etc.

Lit.: 45

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