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Antibiotic synergy against biofilm-forming Pseudomonas aeruginosa
Cernohorská L, Votava M
Jazyk angličtina Země Česko
- MeSH
- antibakteriální látky farmakologie MeSH
- biofilmy účinky léků MeSH
- kombinovaná farmakoterapie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- pseudomonádové infekce farmakoterapie mikrobiologie MeSH
- Pseudomonas aeruginosa fyziologie izolace a purifikace účinky léků MeSH
- synergismus léků MeSH
- Check Tag
- lidé MeSH
Eight antibiotics (aztreonam, ceftazidim, cefoperazon, cefepim, netilmicin, amikacin, ofloxacin and ciprofloxacin) exhibited antimicrobial activity individually and/or in combinations against 20 wild-type biofilm-forming strains of Pseudomonas aeruginosa. The strains were less susceptible in biofilm; in 10 strains antibiotic synergy was observed for the combination of aztreonam and ciprofloxacin. Synergy was also demonstrated in the case of beta-lactams and aminoglycosides, beta-lactams and fluoroquinolones, aminoglycosides and fluoroquinolones, and for monobactams and beta-lactams although the strains were resistant to the individual antibiotics. Synergism or partial synergism was found with one or more antibiotic combinations against 32.4% of isolates.
Lit.: 31
- 000
- 02001naa 2200301 a 4500
- 001
- bmc07508700
- 003
- CZ-PrNML
- 005
- 20111210123307.0
- 008
- 081204s2008 xr e eng||
- 009
- AR
- 024 7_
- $2 doi $a 10.1007/s12223-008-0008-z
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
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- $a xr
- 100 1_
- $a Černohorská, Lenka $7 xx0036697
- 245 10
- $a Antibiotic synergy against biofilm-forming Pseudomonas aeruginosa / $c Cernohorská L, Votava M
- 314 __
- $a Department of Microbiology, Medical School, Masaryk University, and St. Anna's Faculty Hospital, Brno
- 504 __
- $a Lit.: 31
- 520 9_
- $a Eight antibiotics (aztreonam, ceftazidim, cefoperazon, cefepim, netilmicin, amikacin, ofloxacin and ciprofloxacin) exhibited antimicrobial activity individually and/or in combinations against 20 wild-type biofilm-forming strains of Pseudomonas aeruginosa. The strains were less susceptible in biofilm; in 10 strains antibiotic synergy was observed for the combination of aztreonam and ciprofloxacin. Synergy was also demonstrated in the case of beta-lactams and aminoglycosides, beta-lactams and fluoroquinolones, aminoglycosides and fluoroquinolones, and for monobactams and beta-lactams although the strains were resistant to the individual antibiotics. Synergism or partial synergism was found with one or more antibiotic combinations against 32.4% of isolates.
- 650 _2
- $a antibakteriální látky $x farmakologie $7 D000900
- 650 _2
- $a biofilmy $x účinky léků $7 D018441
- 650 _2
- $a synergismus léků $7 D004357
- 650 _2
- $a kombinovaná farmakoterapie $7 D004359
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mikrobiální testy citlivosti $7 D008826
- 650 _2
- $a pseudomonádové infekce $x farmakoterapie $x mikrobiologie $7 D011552
- 650 _2
- $a Pseudomonas aeruginosa $x fyziologie $x izolace a purifikace $x účinky léků $7 D011550
- 700 1_
- $a Votava, Miroslav, $d 1942-2020 $7 jk01150802
- 773 0_
- $w MED00011005 $t Folia microbiologica $g Roč. 53, č. 1 (2008), s. 57-60 $x 0015-5632
- 910 __
- $a ABA008 $b A 2403 $c 561 $y 1
- 990 __
- $a 20080910160324 $b ABA008
- 991 __
- $a 20081204160519 $b ABA008
- 999 __
- $a ok $b bmc $g 624296 $s 476731
- BAS __
- $a 3
- BMC __
- $a 2008 $b 53 $c 1 $d 57-60 $i 0015-5632 $m Folia microbiologica $x MED00011005
- LZP __
- $a 2008-14/mkme
