-
Something wrong with this record ?
Ionizing radiation sensitizes leukemic MOLT-4 cells to TRAIL-induced apoptosis
Martina Řezáčová, Jiřina Vávrová, Doris Vokurková
Language English Country Czech Republic
Digital library NLK
Full text - Article
Issue
Volume
Source
Source
NLK
Directory of Open Access Journals
from 1997
Free Medical Journals
from 1997
Open Access Digital Library
from 1997-01-01
ROAD: Directory of Open Access Scholarly Resources
from 1997
- MeSH
- Apoptosis radiation effects radiation effects MeSH
- Leukemia metabolism pathology MeSH
- Humans MeSH
- Tumor Cells, Cultured drug effects radiation effects MeSH
- TNF-Related Apoptosis-Inducing Ligand pharmacology MeSH
- Radiation Tolerance drug effects MeSH
- Receptors, TNF-Related Apoptosis-Inducing Ligand metabolism MeSH
- Gamma Rays MeSH
- Check Tag
- Humans MeSH
One of perspective approaches in treatment of hematological malignancies is activation of death receptors for TRAIL. However, leukemia cells studied to date have shown variable susceptibility to TRAIL. Our study demonstrates that cells of acute T-lymphoblastic leukemia MOLT-4 are resistant to TRAIL and that ionizing radiation in the therapeutically achievable dose of 1 Gy sensitizes TRAIL-resistant cells MOLT-4 to the TRAIL-induced apoptosis by increase in death receptors for TRAIL DR5. When TRAIL is applied after the irradiation in the time of increased DR5 positivity more efficient cell killing is achieved.
References provided by Crossref.org
Lit.: 18
- 000
- 00000naa 2200000 a 4500
- 001
- bmc07513434
- 003
- CZ-PrNML
- 005
- 20111210124623.0
- 008
- 081204s2008 xr e eng||
- 009
- AR
- 024 7_
- $a 10.14712/18059694.2017.10 $2 doi
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Řezáčová, Martina, $d 1972- $7 nlk20020124956
- 245 10
- $a Ionizing radiation sensitizes leukemic MOLT-4 cells to TRAIL-induced apoptosis / $c Martina Řezáčová, Jiřina Vávrová, Doris Vokurková
- 314 __
- $a Charles University in Prague, Department of Medical Biochemistry, Faculty of Medicine and University Hospital, Hradec Králové
- 504 __
- $a Lit.: 18
- 520 9_
- $a One of perspective approaches in treatment of hematological malignancies is activation of death receptors for TRAIL. However, leukemia cells studied to date have shown variable susceptibility to TRAIL. Our study demonstrates that cells of acute T-lymphoblastic leukemia MOLT-4 are resistant to TRAIL and that ionizing radiation in the therapeutically achievable dose of 1 Gy sensitizes TRAIL-resistant cells MOLT-4 to the TRAIL-induced apoptosis by increase in death receptors for TRAIL DR5. When TRAIL is applied after the irradiation in the time of increased DR5 positivity more efficient cell killing is achieved.
- 650 _2
- $a apoptóza $x účinky záření $x účinky záření $7 D017209
- 650 _2
- $a záření gama $7 D005720
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a leukemie $x metabolismus $x patologie $7 D007938
- 650 _2
- $a tolerance záření $x účinky léků $7 D011836
- 650 _2
- $a TRAIL receptory $x metabolismus $7 D053220
- 650 _2
- $a protein TRAIL $x farmakologie $7 D053221
- 650 _2
- $a nádorové buňky kultivované $x účinky léků $x účinky záření $7 D014407
- 700 1_
- $a Vávrová, Jiřina, $d 1946- $7 xx0004363
- 700 1_
- $a Vokurková, Doris, $7 xx0110367 $d 1958-
- 773 0_
- $w MED00010947 $t Acta medica (Hradec Králové) $g Roč. 51, č. 2 (2008), s. 101-105 $x 1211-4286
- 856 41
- $u https://actamedica.lfhk.cuni.cz/media/pdf/am_2008051020101.pdf $y plný text volně přístupný
- 910 __
- $a ABA008 $b A 3077 $c 1072 $y 9
- 990 __
- $a 20081204091643 $b ABA008
- 991 __
- $a 20090331085431 $b ABA008
- 999 __
- $a ok $b bmc $g 629030 $s 481482
- BAS __
- $a 3
- BMC __
- $a 2008 $b 51 $c 2 $d 101-105 $i 1211-4286 $m Acta Medica $x MED00010947
- LZP __
- $a 2008-21/mkme
