Internalization of Ineffective Platinum Complex in Nanocapsules Renders It Cytotoxic
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
26789279
DOI
10.1002/chem.201504671
Knihovny.cz E-zdroje
- Klíčová slova
- DNA, cancer, liposomes, phospholipids, platinum,
- MeSH
- adukty DNA MeSH
- antitumorózní látky chemie metabolismus farmakologie MeSH
- cisplatina chemie farmakologie MeSH
- DNA chemie účinky léků metabolismus MeSH
- fosfolipidy chemie MeSH
- lidé MeSH
- liposomy chemie MeSH
- nanokapsle chemie MeSH
- platina chemie MeSH
- sloučeniny platiny chemie farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adukty DNA MeSH
- antitumorózní látky MeSH
- cisplatina MeSH
- DNA MeSH
- fosfolipidy MeSH
- liposomy MeSH
- nanokapsle MeSH
- platina MeSH
- sloučeniny platiny MeSH
Anticancer therapy by platinum complexes, based on nanocarrier-based delivery, may offer a new approach to improve the efficacy and tolerability of the platinum family of anticancer drugs. The original rules for the design of new anticancer platinum drugs were affected by the fact that, although cisplatin (cis-[PtCl2 (NH3)2) was an anticancer drug, its isomer transplatin was not cytotoxic. For the first time, it is demonstrated that simple encapsulation of an inactive platinum compound in phospholipid bilayers transforms it into an efficient cytotoxic agent. Notably, the encapsulation of transplatin makes it possible to overcome the resistance mechanisms operating in cancer cells treated with cisplatin and prevents inactivation of transplatin in the extracellular environment. It is also shown that transplatin delivered to the cells in nanocapsules, in contrast to free (nonencapsulated) complex, forms cytotoxic cross-links on DNA.
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