-
Something wrong with this record ?
Separation and determination of clotrimazole, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography
Hamoudová R., Pospíšilová M., Kavalírová A., Solich P., Šícha J.
Language English Country Great Britain
Grant support
NL7689
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
NLK
ScienceDirect (archiv)
from 1993-01-01 to 2009-12-31
- MeSH
- Anti-Infective Agents, Local analysis chemistry MeSH
- Time Factors MeSH
- Models, Chemical MeSH
- Chemistry Techniques, Analytical methods MeSH
- Chromatography, Micellar Electrokinetic Capillary methods MeSH
- Sodium Dodecyl Sulfate chemistry MeSH
- Electrolytes MeSH
- Chemistry, Pharmaceutical methods MeSH
- Financing, Organized MeSH
- Phosphates analysis MeSH
- Calibration MeSH
- Clotrimazole analysis chemistry MeSH
- Hydrogen-Ion Concentration MeSH
- Preservatives, Pharmaceutical analysis MeSH
- Parabens analysis chemistry MeSH
- Surface-Active Agents analysis MeSH
- Reproducibility of Results MeSH
- Sensitivity and Specificity MeSH
- Temperature MeSH
- Chromatography, High Pressure Liquid MeSH
In this study, micellar electrokinetic chromatography (MEKC) method was developed for the determination of clotrimazole (CLO), methylparaben (MP) and propylparaben (PP) in a pharmaceutical preparation. Separation was carried out in a fused silica capillary (60 cm x 75 microm i.d.) at 25 kV with UV detection at 212 nm. Optimized background electrolyte (BGE) was 15 mM phosphate buffer (pH 7.2) containing 30 mM sodium dodecyl sulfate (SDS) as a surfactant. Rectilinear calibration ranges were 50-500 mg l(-1) for CLO, 10-100 mg l(-1) for MP and 2.5-25 mg l(-1) for PP. The total analysis time was < 12 min.
- 000
- 00000naa 2200000 a 4500
- 001
- bmc07520256
- 003
- CZ-PrNML
- 005
- 20130326073038.0
- 008
- 090330s2006 xxk e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Hamoudová, Rafifa $7 xx0127803
- 245 10
- $a Separation and determination of clotrimazole, methylparaben and propylparaben in pharmaceutical preparation by micellar electrokinetic chromatography / $c Hamoudová R., Pospíšilová M., Kavalírová A., Solich P., Šícha J.
- 314 __
- $a Charles University, Faculty of Pharmacy, Department of Analytical Chemistry, Heyrovského 1203, CZ-500 05 Hradec Králové, Czech Republic
- 520 9_
- $a In this study, micellar electrokinetic chromatography (MEKC) method was developed for the determination of clotrimazole (CLO), methylparaben (MP) and propylparaben (PP) in a pharmaceutical preparation. Separation was carried out in a fused silica capillary (60 cm x 75 microm i.d.) at 25 kV with UV detection at 212 nm. Optimized background electrolyte (BGE) was 15 mM phosphate buffer (pH 7.2) containing 30 mM sodium dodecyl sulfate (SDS) as a surfactant. Rectilinear calibration ranges were 50-500 mg l(-1) for CLO, 10-100 mg l(-1) for MP and 2.5-25 mg l(-1) for PP. The total analysis time was < 12 min.
- 650 _2
- $a antiinfekční látky lokální $x analýza $x chemie $7 D000891
- 650 _2
- $a kalibrace $7 D002138
- 650 _2
- $a chemické techniky analytické $x metody $7 D002623
- 650 _2
- $a farmaceutická chemie $x metody $7 D002626
- 650 _2
- $a vysokoúčinná kapalinová chromatografie $7 D002851
- 650 _2
- $a chromatografie micelární elektrokinetická kapilární $x metody $7 D020374
- 650 _2
- $a klotrimazol $x analýza $x chemie $7 D003022
- 650 _2
- $a elektrolyty $7 D004573
- 650 _2
- $a koncentrace vodíkových iontů $7 D006863
- 650 _2
- $a chemické modely $7 D008956
- 650 _2
- $a parabeny $x analýza $x chemie $7 D010226
- 650 _2
- $a fosfáty $x analýza $7 D010710
- 650 _2
- $a konzervační prostředky farmaceutické $x analýza $7 D011310
- 650 _2
- $a reprodukovatelnost výsledků $7 D015203
- 650 _2
- $a senzitivita a specificita $7 D012680
- 650 _2
- $a dodecylsíran sodný $x chemie $7 D012967
- 650 _2
- $a povrchově aktivní látky $x analýza $7 D013501
- 650 _2
- $a teplota $7 D013696
- 650 _2
- $a časové faktory $7 D013997
- 650 _2
- $a financování organizované $7 D005381
- 700 1_
- $a Pospíšilová, Marie, $d 1946- $7 xx0063894
- 700 1_
- $a Kavalírová, Andrea $7 xx0127938
- 700 1_
- $a Solich, Petr, $d 1955- $7 jo2007285395
- 700 1_
- $a Šícha, Jan $7 xx0098332
- 773 0_
- $w MED00002894 $t Journal of pharmaceutical and biomedical analysis $g Roč. 40, č. 1 (2006), s. 215-219 $x 0731-7085
- 910 __
- $a ABA008 $b x $y 9
- 990 __
- $a 20090312170439 $b ABA008
- 991 __
- $a 20130326073259 $b ABA008
- 999 __
- $a ok $b bmc $g 638059 $s 490857
- BAS __
- $a 3
- BMC __
- $a 2006 $b 40 $c 1 $d 215-219 $i 0731-7085 $m Journal of pharmaceutical and biomedical analysis $x MED00002894
- GRA __
- $a NL7689 $p MZ0
- LZP __
- $a 2009-B1/vtme
