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Investigation of the mechanism of action of 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans by flow cytometry
Vale-Silva LA, Buchta V, Vokurková D, Pour M.
Bioorganic & medicinal chemistry letters.
2006 ;
16 (9) :
2492-2495.
Jazyk angličtina Země Velká Británie
Perzistentní odkaz
https://www.medvik.cz/link/bmc07521362
Online
NLK
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
- MeSH
- antifungální látky farmakologie chemie MeSH
- Candida albicans účinky léků MeSH
- financování organizované MeSH
- furany farmakologie chemie MeSH
- mikrobiální testy citlivosti MeSH
- průtoková cytometrie metody MeSH
The mechanism of action of the antifungal agent 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans was investigated by flow cytometry, using propidium iodide, DiBAC4(3), and FUN-1 as the fluorescent dyes. A related but less active agent, together with amphotericin B and fluconazole, was tested in parallel for comparison of the results. The incrustoporine derivative was found to have a potent fungicidal activity on C. albicans, resulting in damage of cell membrane.
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