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The late-stage foetal liver microenvironment is essential for later sensitivity of B-lymphopoiesis to suppression by oestrogens
Tereza Pelichovská, Chang KT, Luděk Šefc, Filipp Savvulidi, Petr Broulík, Emanuel Nečas
Language English Country Czech Republic
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Free Medical Journals
from 2000
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ProQuest Central
from 2005-01-01
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from 2005-01-01
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- MeSH
- B-Lymphocytes physiology drug effects MeSH
- Estrogens pharmacology MeSH
- Hematopoietic Stem Cells physiology drug effects MeSH
- Liver physiology MeSH
- Lymphopoiesis physiology drug effects MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Fetus anatomy & histology physiology MeSH
- Radiation Chimera MeSH
- Pregnancy MeSH
- Stem Cell Transplantation MeSH
- Environment MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
B-lymphopoiesis in FL differs notably from that of adult B-lymphopoiesis in being resistant to suppression by oestrogens due to the lack of expression of oestrogen receptors in B-cell progenitors and precursors. We have transplanted middle-stage FL cells (E14.5) to adult male mice and demonstrated that B-lymphopoiesis derived from FL cells remained resistant to suppression by exogenous oestrogen for several months compared to adult BM cells. This significant difference strongly suggests that the latestage FL environment exerts an inductive action on the haematopoietic stem cells and is mandatory for later sensitivity of B-lymphopoiesis to suppression by oestrogens. The results also provide the first in vivo functional confirmation of a differential responsiveness of FL- and adult BM-derived B-lymphopoiesis to suppression by oestrogens.
Lit.: 23
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- $a B-lymphopoiesis in FL differs notably from that of adult B-lymphopoiesis in being resistant to suppression by oestrogens due to the lack of expression of oestrogen receptors in B-cell progenitors and precursors. We have transplanted middle-stage FL cells (E14.5) to adult male mice and demonstrated that B-lymphopoiesis derived from FL cells remained resistant to suppression by exogenous oestrogen for several months compared to adult BM cells. This significant difference strongly suggests that the latestage FL environment exerts an inductive action on the haematopoietic stem cells and is mandatory for later sensitivity of B-lymphopoiesis to suppression by oestrogens. The results also provide the first in vivo functional confirmation of a differential responsiveness of FL- and adult BM-derived B-lymphopoiesis to suppression by oestrogens.
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