Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Determination of angiogenic factors in serum by protein array in patients with renal cell carcinoma

Šárka Lukešová, Otakar Kopecký, Vladimíra Vroblová, Dagmar Hlávková, Ctirad Andrýs, Petr Morávek, Eva Čermáková

. 2008 ; 54 (4) : 134-140.

Jazyk angličtina Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc07523172

Grantová podpora
NR8914 MZ0 CEP - Centrální evidence projektů

Using the protein array method we determined the serum levels of a number of angiogenic factors. We identified serum levels of angiogenin, PDGF and MCP-1 (CCL2 chemokine) in serum of 32 patients with RCC, and 14 healthy volunteers by means of antibody array analysis. The patients were divided into three groups according to their disease stages (I+II, III, and IV). We found significant differences between the controls and patients with RCC both pre-operatively and post-operatively in angiogenin, PDGF and MCP-1 serum levels. The increase in angiogenin, PDGF and MCP-1 lasted in patients with RCC stages I-III even without metastases eight weeks post-operatively. The patients with stage IV RCC showed disturbed production of PDGF and MCP-1. Protein array analysis is a powerful tool for the identification of large numbers of trace proteins. Multiplex antibody array is able to provide data more precisely reflecting the nature of pathological processes.

Bibliografie atd.

Lit.: 34

000      
00000naa 2200000 a 4500
001      
bmc07523172
003      
CZ-PrNML
005      
20130312105728.0
008      
090514s2008 xr e eng||
009      
AR
035    __
$a (PubMed)18808740
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Lukešová, Šárka $7 xx0078669
245    10
$a Determination of angiogenic factors in serum by protein array in patients with renal cell carcinoma / $c Šárka Lukešová, Otakar Kopecký, Vladimíra Vroblová, Dagmar Hlávková, Ctirad Andrýs, Petr Morávek, Eva Čermáková
314    __
$a Charles University in Prague, Faculty of Medicine and University Teaching Hospital, Hradec Králové
504    __
$a Lit.: 34
520    9_
$a Using the protein array method we determined the serum levels of a number of angiogenic factors. We identified serum levels of angiogenin, PDGF and MCP-1 (CCL2 chemokine) in serum of 32 patients with RCC, and 14 healthy volunteers by means of antibody array analysis. The patients were divided into three groups according to their disease stages (I+II, III, and IV). We found significant differences between the controls and patients with RCC both pre-operatively and post-operatively in angiogenin, PDGF and MCP-1 serum levels. The increase in angiogenin, PDGF and MCP-1 lasted in patients with RCC stages I-III even without metastases eight weeks post-operatively. The patients with stage IV RCC showed disturbed production of PDGF and MCP-1. Protein array analysis is a powerful tool for the identification of large numbers of trace proteins. Multiplex antibody array is able to provide data more precisely reflecting the nature of pathological processes.
650    _2
$a senioři $7 D000368
650    _2
$a karcinom z renálních buněk $x chirurgie $x krev $x patologie $7 D002292
650    _2
$a chemokin CCL2 $x krev $7 D018932
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a destičkový růstový faktor $x metabolismus $7 D010982
650    _2
$a čipová analýza proteinů $7 D040081
650    _2
$a pankreatická ribonukleasa $x krev $7 D012259
700    1_
$a Kopecký, Otakar, $d 1955- $7 jn20000401408
700    1_
$a Vroblová, Vladimíra $7 xx0104044
700    1_
$a Hlávková, Dagmar $7 xx0092235
700    1_
$a Andrýs, Ctirad, $d 1962- $7 mzk2008430528
700    1_
$a Morávek, Petr, $d 1942- $7 jn99240000736
700    1_
$a Čermáková, Eva, $d 1952- $7 mzk2007401286
773    0_
$w MED00011004 $t Folia biologica $g Roč. 54, č. 4 (2008), s. 134-140 $x 0015-5500
856    41
$u https://fb.cuni.cz/Data/files/folia_biologica/volume_54_2008_4/FB2008A0023.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 970 $c 89 $y 9
990    __
$a 20090513150919 $b ABA008
991    __
$a 20130312105943 $b ABA008
999    __
$a ok $b bmc $g 651260 $s 504432
BAS    __
$a 3
BMC    __
$a 2008 $b 54 $c 4 $d 134-140 $i 0015-5500 $m Folia biologica (Praha) $x MED00011004
GRA    __
$a NR8914 $p MZ0
LZP    __
$a 2009-18/mkme

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace