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Peroral IMUNOR, a low-molecular-weight immunomodulator prepared from disintegrated and ultrafiltered leukocytes, enhances recovery from myelosuppression induced by cisplatin or 5-fluorouracil
Hofer M., Vacek A., Holá J., Weiterová L., Streitová D.
Immunopharmacology and immunotoxicology.
2006 ;
28 (1) :
1-11.
Jazyk angličtina Země Spojené státy americké
Perzistentní odkaz
https://www.medvik.cz/link/bmc07523384
- MeSH
- buňky kostní dřeně imunologie účinky léků MeSH
- cisplatina MeSH
- financování organizované MeSH
- fluoruracil MeSH
- granulocyty imunologie účinky léků MeSH
- hematopoéza účinky léků MeSH
- imunologické faktory farmakologie chemie MeSH
- kmenové buňky účinky léků MeSH
- leukocyty chemie imunologie MeSH
- myši inbrední ICR MeSH
- myši MeSH
- nemoci kostní dřeně farmakoterapie chemicky indukované MeSH
- prasata MeSH
- protinádorové antimetabolity MeSH
- protinádorové látky MeSH
- ultrafiltrace MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
A single dose of IMUNOR, a low-molecular-weight immunodulator prepared from disintegrated and ultrafiltered pig leukocytes, was found to enhance recovery of murine pool of hemopoietic progenitor cells for granulocytes and macrophages damaged by a single injection of cytotoxic drugs 5-fluorouracil or cisplatin. The best results were obtained after the treatment with IMUNOR on days 3 or 4 after the injection of 5-fluorouracil or cisplatin. These results together with previous findings obtained in our laboratory suggest that IMUNOR has the potential to become a part of treatment schemes in oncological practice aimed at alleviation of myelosuppression evoked by cytotoxic anti-tumor therapy.
Citace poskytuje Crossref.org
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