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The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis
Vítek L, Novotný L, Sperl M, Holaj R, Spácil J.
Jazyk angličtina Země Švýcarsko
NLK
Karger Journals
od 1991 do 2009
ProQuest Central
od 1997-01-01 do 2015-11-30
Medline Complete (EBSCOhost)
od 2005-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do 2015-11-30
- MeSH
- arteria carotis communis patologie ultrasonografie MeSH
- bilirubin krev MeSH
- biologické markery krev MeSH
- dospělí MeSH
- financování organizované MeSH
- Gilbertova nemoc krev patologie MeSH
- jaterní testy MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- tunica intima patologie ultrasonografie MeSH
- tunica media patologie ultrastruktura MeSH
- věkové faktory MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
BACKGROUND: Serum bilirubin is negatively associated with the development of coronary heart disease. In the present study, we have focused on the analysis of intima-media thickness (IMT) of the common carotid artery in hyper- and normobilirubinemic subjects. METHODS: The study was performed on 111 men without manifested atherosclerosis. In all subjects, complete biochemical tests were determined along with the examination of IMT by carotid ultrasound. RESULTS: The mean IMT in hyperbilirubinemic subjects as compared with controls was substantially lower (p=0.017), and hyperbilirubinemic men also had very low age-adjusted prevalence odds ratios for having IMT above the 50th percentiles of controls, even after adjustment for selected vascular risk factors (p=0.034). CONCLUSIONS: In the present study, we demonstrate the inverse relationship between serum bilirubin and IMT in healthy men. Copyright (c) 2006 S. Karger AG, Basel.
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- $a The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis / $c Vítek L, Novotný L, Sperl M, Holaj R, Spácil J.
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- $a 4th Department of Internal Medicine and Institute of Clinical Biochemistry and Laboratory Diagnostics, Charles University, Prague, Czech Republic. vitek@cesnet.cz
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- $a BACKGROUND: Serum bilirubin is negatively associated with the development of coronary heart disease. In the present study, we have focused on the analysis of intima-media thickness (IMT) of the common carotid artery in hyper- and normobilirubinemic subjects. METHODS: The study was performed on 111 men without manifested atherosclerosis. In all subjects, complete biochemical tests were determined along with the examination of IMT by carotid ultrasound. RESULTS: The mean IMT in hyperbilirubinemic subjects as compared with controls was substantially lower (p=0.017), and hyperbilirubinemic men also had very low age-adjusted prevalence odds ratios for having IMT above the 50th percentiles of controls, even after adjustment for selected vascular risk factors (p=0.034). CONCLUSIONS: In the present study, we demonstrate the inverse relationship between serum bilirubin and IMT in healthy men. Copyright (c) 2006 S. Karger AG, Basel.
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