-
Je něco špatně v tomto záznamu ?
Fibroblast growth factor signaling in embryonic and cancer stem cells
Dvorak P, Dvorakova D, Hampl A.
Jazyk angličtina Země Nizozemsko
Typ dokumentu přehledy
NLK
Free Medical Journals
od 1968 do 2015
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
Wiley Free Content
od 1997 do Před 1 rokem
- MeSH
- embryo savčí cytologie mikrobiologie MeSH
- fibroblastové růstové faktory metabolismus MeSH
- financování organizované MeSH
- hematologické nádory metabolismus patologie MeSH
- kmenové buňky metabolismus MeSH
- kultivované buňky MeSH
- lidé MeSH
- signální transdukce MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Cancer stem cells are cancer cells that originate from the transformation of normal stem cells. The most important property of any stem cell is the ability to self-renew. Through this property, there are striking parallels between normal stem cells and cancer stem cells. Both cell types share various markers of "stemness". In particular, normal stem cells and cancer stem cells utilize similar molecular mechanisms to drive self-renewal, and similar signaling pathways may induce their differentiation. The fibroblast growth factor 2 (FGF-2) pathway is one of the most significant regulators of human embryonic stem cell (hESC) self-renewal and cancer cell tumorigenesis. Here we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also, we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes.
Citace poskytuje Crossref.org
- 000
- 00000naa 2200000 a 4500
- 001
- bmc07523710
- 003
- CZ-PrNML
- 005
- 20111210140025.0
- 008
- 090524s2006 ne e eng||
- 009
- AR
- 024 __
- $a 10.1016/j.febslet.2006.01.095 $2 doi
- 035 __
- $a (PubMed)16516203
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Dvořák, Petr, $d 1956- $7 ola2002153627
- 245 10
- $a Fibroblast growth factor signaling in embryonic and cancer stem cells / $c Dvorak P, Dvorakova D, Hampl A.
- 314 __
- $a Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic. pdvorak@med.muni.cz
- 520 9_
- $a Cancer stem cells are cancer cells that originate from the transformation of normal stem cells. The most important property of any stem cell is the ability to self-renew. Through this property, there are striking parallels between normal stem cells and cancer stem cells. Both cell types share various markers of "stemness". In particular, normal stem cells and cancer stem cells utilize similar molecular mechanisms to drive self-renewal, and similar signaling pathways may induce their differentiation. The fibroblast growth factor 2 (FGF-2) pathway is one of the most significant regulators of human embryonic stem cell (hESC) self-renewal and cancer cell tumorigenesis. Here we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also, we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes.
- 650 _2
- $a kultivované buňky $7 D002478
- 650 _2
- $a embryo savčí $x cytologie $x mikrobiologie $7 D004622
- 650 _2
- $a fibroblastové růstové faktory $x metabolismus $7 D005346
- 650 _2
- $a hematologické nádory $x metabolismus $x patologie $7 D019337
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a signální transdukce $7 D015398
- 650 _2
- $a kmenové buňky $x metabolismus $7 D013234
- 650 _2
- $a financování organizované $7 D005381
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Dvořáková, Dana, $d 1957- $7 xx0070713
- 700 1_
- $a Hampl, Aleš, $d 1962- $7 ola2002153626
- 773 0_
- $w MED00001785 $t FEBS letters $g Roč. 580, č. 12 (2006), s. 2869-2874 $x 0014-5793
- 910 __
- $a ABA008 $b x $y 9
- 990 __
- $a 20090506084234 $b ABA008
- 991 __
- $a 20091116130202 $b ABA008
- 999 __
- $a ok $b bmc $g 656785 $s 510104
- BAS __
- $a 3
- BMC __
- $a 2006 $b 580 $c 12 $d 2869-2874 $i 0014-5793 $m FEBS letters $x MED00001785
- LZP __
- $a 2009-B2/vtme
