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The effect of microelements supplementation on beta-oxidation activity in healthy and type 1 diabetic rats
Tomasz Kuryl, Bogdan Debski, Karel Martinik
Language English Country Czech Republic
Digital library NLK
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- MeSH
- Diabetes Mellitus, Type 1 blood metabolism MeSH
- Diabetes Mellitus, Experimental diet therapy metabolism MeSH
- Financing, Organized MeSH
- Weight Gain drug effects MeSH
- Insulin metabolism MeSH
- Blood Glucose metabolism drug effects MeSH
- Rats MeSH
- Lymphocytes radiation effects MeSH
- Fatty Acids pharmacokinetics metabolism MeSH
- Oxidation-Reduction drug effects MeSH
- Rats, Wistar MeSH
- Dietary Supplements MeSH
- Chromium Compounds pharmacology metabolism MeSH
- Selenium Compounds pharmacology metabolism MeSH
- Trace Elements administration & dosage metabolism MeSH
- Streptozocin administration & dosage metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
Diabetes mellitus type 1 disease changes the activity of fatty acid degradation as compared to healthy animals. Supplementation in vitro with microelements chromium Cr3+ and selenium Se4+ and Se2- in non-toxic ([96.15 pmol (5 ppm) for chromium and 6.33 micromol (0.5 ppm) for selenium] concentrations strongly stimulates the activity of this process in diabetic rats. In healthy animals only chromium Cr3+ in concentration of 96.15 micromol (5 ppm) stimulated beta-oxidation activity in lymphocytes. It may indicate the beneficial effect of supplementation of the diet with microelements, chromium Cr3 and selenium Se4+ or Se2- at concentrations as low as 100 micromol for chromium and 6 micromol for selenium, respectively.
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Lit.: 32
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