Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

The effect of S-nitrosocaptopril and S-nitroso-N-acetyl-D,L- penicillamine on blood glucose concentration and haemodynamic parameters

Sacha Campbell, Ruby Alexander-Lindo, Tara Dasgupta, Donovan McGrowder

. 2009 ; 7 (3) : 123-131.

Jazyk angličtina Země Česko

Typ dokumentu tabulky

Perzistentní odkaz   https://www.medvik.cz/link/bmc09002356

Studies have shown that S-nitrosothiols (RSNOs) are able to affect glucose metabolism and blood pressure in animal models. This paper describes an investigation into the effect of two RSNOs, S-nitrosocaptopril (CapSNO) and S-nitroso-N-acetyl-D,L-penicillamine (SNAP) on fasting and postprandial blood glucose concentration, and systolic and diastolic blood pressures. Rats administered intravenously with CapSNO and SNAP, using dosages of 2.0, 5.0 and 12.5 mg/kg BW, showed a dose-dependent hyperglycaemic effect. Intravenous administration of 12.5 mg/kg BW of CapSNO and SNAP caused a statistically significant increase in fasting blood glucose concentration compared to rats treated with the same dosage of captopril. SNAP-treated rats showed a significantly greater elevation of fasting (F2) blood glucose concentration (5.91 ± 0.27 mmol/l) compared to CapSNO-treated rats (5.11 ± 0.08 mmol/l. However there was no significant difference in postprandial blood glucose concentrations. SNAP, CapSNO and captopril significantly reduced both systolic and diastolic blood pressures. This was accompanied by an increase in heart rate. The anti-hypertensive property of CapSNO and SNAP was more significant than that of captopril. CapSNO was more potent than SNAP in reducing blood pressure, suggesting that CapSNO may act via a combined mechanism that involves ACE inhibition and NO release.

Citace poskytuje Crossref.org

Bibliografie atd.

Lit.: 38

000      
00000naa 2200000 a 4500
001      
bmc09002356
003      
CZ-PrNML
005      
20111210152434.0
008      
091105s2009 xr e eng||
009      
AR
024    7_
$a 10.32725/jab.2009.013 $2 doi
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Campbell, Sacha
245    14
$a The effect of S-nitrosocaptopril and S-nitroso-N-acetyl-D,L- penicillamine on blood glucose concentration and haemodynamic parameters / $c Sacha Campbell, Ruby Alexander-Lindo, Tara Dasgupta, Donovan McGrowder
314    __
$a Donovan McGrowder, Department of Pathology, Faculty of Medical Sciences, University of the West Indies, Mona Campus, Kingston, Jamaica
504    __
$a Lit.: 38
520    9_
$a Studies have shown that S-nitrosothiols (RSNOs) are able to affect glucose metabolism and blood pressure in animal models. This paper describes an investigation into the effect of two RSNOs, S-nitrosocaptopril (CapSNO) and S-nitroso-N-acetyl-D,L-penicillamine (SNAP) on fasting and postprandial blood glucose concentration, and systolic and diastolic blood pressures. Rats administered intravenously with CapSNO and SNAP, using dosages of 2.0, 5.0 and 12.5 mg/kg BW, showed a dose-dependent hyperglycaemic effect. Intravenous administration of 12.5 mg/kg BW of CapSNO and SNAP caused a statistically significant increase in fasting blood glucose concentration compared to rats treated with the same dosage of captopril. SNAP-treated rats showed a significantly greater elevation of fasting (F2) blood glucose concentration (5.91 ± 0.27 mmol/l) compared to CapSNO-treated rats (5.11 ± 0.08 mmol/l. However there was no significant difference in postprandial blood glucose concentrations. SNAP, CapSNO and captopril significantly reduced both systolic and diastolic blood pressures. This was accompanied by an increase in heart rate. The anti-hypertensive property of CapSNO and SNAP was more significant than that of captopril. CapSNO was more potent than SNAP in reducing blood pressure, suggesting that CapSNO may act via a combined mechanism that involves ACE inhibition and NO release.
650    _2
$a krevní glukóza $x izolace a purifikace $x účinky léků $7 D001786
650    _2
$a hyperglykemie $x krev $x metabolismus $7 D006943
650    _2
$a krevní tlak $x účinky léků $7 D001794
650    _2
$a hemodynamika $x účinky léků $7 D006439
650    _2
$a postprandiální období $x účinky léků $7 D019518
650    _2
$a omezení příjmu potravy $7 D005215
650    _2
$a S-nitrosothioly $x diagnostické užití $7 D026403
650    _2
$a S-nitroso-N-acetylpenicilamin $x diagnostické užití $7 D026423
650    _2
$a kaptopril $x analogy a deriváty $x diagnostické užití $7 D002216
650    _2
$a experimenty na zvířatech $x statistika a číselné údaje $7 D032761
650    _2
$a potkani Wistar $x krev $x metabolismus $7 D017208
650    _2
$a statistika jako téma $7 D013223
650    _2
$a zvířata $7 D000818
655    _2
$a tabulky $7 D020501
700    1_
$a Alexander-Lindo, Ruby $7 gn_A_00003926
700    1_
$a Dasgupta, Tara
700    1_
$a McGrowder, Donovan
773    0_
$w MED00012667 $t Journal of applied biomedicine $g Roč. 7, č. 3 (2009), s. 123-131 $x 1214-021X
856    41
$u https://jab.zsf.jcu.cz/pdfs/jab/2009/03/02.pdf $y plný text volně přístupný
910    __
$a ABA008 $b B 2301 $c 1249 $y 8
990    __
$a 20091105101214 $b ABA008
991    __
$a 20110222093311 $b ABA008
999    __
$a ok $b bmc $g 691527 $s 553426
BAS    __
$a 3
BMC    __
$a 2009 $b 7 $c 3 $d 123-131 $i 1214-021X $m Journal of Applied Biomedicine $x MED00012667
LZP    __
$a 2009-59/vtal

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...