Aims: To evaluate the iodine status of patients in early pregnancy and its dependence on level of thyroid-stimulatinghormone (TSH). Methods: Between June 2005 and December 2006, 168 patients with a confi rmed vital pregnancy (up to 10th weekof pregnancy) were included in the study. The entry criteria were no prior thyroid disease, did not take any othermedication, had not undergone radio-iodine therapy and did not take multivitamins containing iodine. The iodinestatus was measured as the amount of iodine in urine over 24 hours. The TSH level was determined from the bloodusing chemiluminescence. Results: The average ioduria value in patients was found to be 3.04 µmol/24 hr, with the norm 0.6–2.4 µmol/24 hr, median 2.9, SD 1.5. None of the patients had a value lower than 0.9 µmol/24 hr. The average TSH value was1.98 mIU/l, median was 1.31, SD 0.98. The laboratory limits were set to 0.25–3 mIU/l for pregnant women in thefi rst trimester. Three pregnancies ended in miscarriage by week 12, 1 miscarriage occurred in week 22 and the otherpregnancies concluded in delivery between weeks 38-41. Fourteen patients had TSH levels above 3 mIU/l with normallevels od free thyroxine (T4) : 10.3–25 pmol/l. Conclusions: The results of this study did not reveal any iodine defi cit in any of the patients. However 14 patientshad elevated TSH levels signalling subclinical or incipiently clinical hypothyroidism. These pacients underwent levothyroxinetherapy after endocrinologist’s consultations.

Department of Obstetrics and Gynecology Jesenik Hospital Jesenik

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