Background: Several studies suggest that changes in estrogens and androgens during menopause play a role in theregulation of leptin production. Some authors present hypothesis that sex hormone replacement therapy can modulateleptin levels but up to date evidence shows that the infl uence of endogenous estrogens, androgens levels and sexhormone therapy on leptin concentration remains uncertain.Aim: To evaluate the infl uence of surgically induced menopause on serum leptin levels and the infl uence of diff erenttypes of hormonal therapy on serum leptin concentrations.Methods: 58 women with surgically induced menopause were divided into three groups. Women who did not receiveany hormonal substitution (group 1), women who received Estradiol l mg per day (group 2) and women who receivedTibolone 2,5 mg per day (group3). The levels of leptin, estradiol, testosterone, testosterone, dehydroepiandrosteronesulfate, FSH, LH and progesterone were measured in all subjects on the 5th day and after 3 months following thesurgical procedure.Results: Mean serum leptin concentrations did not diff er statistically in any of the studied groups in the beginingand in the end of the study. There was no correlations between serum leptin and estradiol, LH, FSH, progesterone,testosterone, free testosterone and DHEAS concentrations in any of groups before and after treatment.Conclusion: Changes in sex hormone concentrations caused by ovariectomy do not infl uence serum leptin concentrations.Also the short term administration of low dose estrogen therapy or tibolone in postmenopausal subjectsdoes not change serum leptin levels.

Department of Obsteric and Gynecology University Hospital Ostrava

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