• Je něco špatně v tomto záznamu ?

J774 macrophage-like cell line cytokine and chemokine patterns are modulated by Francisella tularensis LVS strain infection

Holicka M, Novosad J, Kudlova M, Loudova M, Andrys C, Krejsek J.

. 2010 ; 55 (2) : 191-200.

Jazyk angličtina Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc10013085

Mutual interactions were investigated between intracellular parasitic bacterium Francisella tularensis (F.t.; highly virulent bacterium responsible for tularemia, replicating within the host macrophages) and murine macrophage-like cell line J774. Recombinant murine lymphokine INF-gamma and/or LPS derived from E. coli were determined to stimulate in vitro antimicrobial activity of macrophage-like J774 cell line against the live vaccine strain (LVS) of F.t. through their ability to produce proinflammatory cytokines and chemokines. F.t. infection up-regulated IL-12 p40 production and down-regulated TNF-alpha production by stimulated macrophages; on the other hand, F.t. infection did not affect the production of IL-8, IL-6, MCP-5, and RANTES by stimulated macrophages. This showed that F.t. infection modulates the cytokine synthesis by J774 macrophage cell line.

Bibliografie atd.

Lit.: 37

000      
00000naa 2200000 a 4500
001      
bmc10013085
003      
CZ-PrNML
005      
20111210163755.0
008      
101124s2010 xr e eng||
009      
AR
024    7_
$2 doi $a 10.1007/s12223-010-0028-3
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Holická-Černá, Monika $7 xx0075609
245    10
$a J774 macrophage-like cell line cytokine and chemokine patterns are modulated by Francisella tularensis LVS strain infection / $c Holicka M, Novosad J, Kudlova M, Loudova M, Andrys C, Krejsek J.
314    __
$a Department of Clinical Immunology and Allergology, University Hospital and School of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralové
504    __
$a Lit.: 37
520    9_
$a Mutual interactions were investigated between intracellular parasitic bacterium Francisella tularensis (F.t.; highly virulent bacterium responsible for tularemia, replicating within the host macrophages) and murine macrophage-like cell line J774. Recombinant murine lymphokine INF-gamma and/or LPS derived from E. coli were determined to stimulate in vitro antimicrobial activity of macrophage-like J774 cell line against the live vaccine strain (LVS) of F.t. through their ability to produce proinflammatory cytokines and chemokines. F.t. infection up-regulated IL-12 p40 production and down-regulated TNF-alpha production by stimulated macrophages; on the other hand, F.t. infection did not affect the production of IL-8, IL-6, MCP-5, and RANTES by stimulated macrophages. This showed that F.t. infection modulates the cytokine synthesis by J774 macrophage cell line.
650    _2
$a financování organizované $7 D005381
650    _2
$a zvířata $7 D000818
650    _2
$a buněčné linie $7 D002460
650    _2
$a chemokiny $x imunologie $7 D018925
650    _2
$a cytokiny $x imunologie $7 D016207
650    _2
$a Francisella tularensis $x imunologie $7 D005604
650    _2
$a makrofágy $x imunologie $x mikrobiologie $7 D008264
650    _2
$a myši $7 D051379
650    _2
$a tularemie $x imunologie $x mikrobiologie $7 D014406
700    1_
$a Novosad, Jakub, $d 1978- $7 xx0074937
700    1_
$a Trojáčková Kudlová, Manuela $7 xx0083626
700    1_
$a Loudová, Martina $7 xx0074942
700    1_
$a Krejsek, Jan, $d 1958- $7 nlk19990073429
700    1_
$a Andrýs, Ctirad, $d 1962- $7 mzk2008430528
773    0_
$w MED00011005 $t Folia microbiologica $g Roč. 55, č. 2 (2010), s. 191-200 $x 0015-5632
910    __
$a ABA008 $b A 2403 $c 561 $y 8
990    __
$a 20100531103706 $b ABA008
991    __
$a 20110930110041 $b ABA008
999    __
$a ok $b bmc $g 729746 $s 592952
BAS    __
$a 3
BMC    __
$a 2010 $b 55 $c 2 $d 191-200 $m Folia microbiologica $x MED00011005
LZP    __
$a 2010-15/mkme

Najít záznam