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Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response
Aleš Tichý, Jiřina Vávrová, Jaroslav Pejchal, Martina Řezáčová
Jazyk angličtina Země Česko
Digitální knihovna NLK
Plný text - Článek
Číslo
Ročník
Zdroj
Zdroj
NLK
Directory of Open Access Journals
od 1997
Free Medical Journals
od 1997
Open Access Digital Library
od 1997-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1997
- MeSH
- financování organizované MeSH
- geny p53 MeSH
- oprava DNA MeSH
- poškození DNA účinky záření MeSH
- teleangiektatická ataxie genetika MeSH
Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key regulatory enzyme in the terms of ionizing radiationinduced DNA damage.
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Lit.: 64
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