Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Dissociation, forced normalization and dynamic multi-stability of the brain

Petr Bob

. 2007 ; 28 (3) : 231-246.

Language English Country Sweden

Document type Review

Grant support
NR8824 MZ0 CEP Register

Dissociated states represent pathological conditions where psychological trauma may emerge in a variety of forms such as psychic dissociative symptoms (hallucinations, derealization etc.) or on the other hand as somatoform symptoms (paroxysms, loss of motor control, involuntary movements etc.). Recent findings suggest that neurophysiological level of dissociative phenomena may be linked to the same neurophysiological principles that emerge in multi-stable perception of ambiguous stimuli likely caused by competing interpretations with mutual exclusivity. At this time there is evidence that temporal lobe seizure activity can produce dissociative syndrome and from these findings may be inferred that temporal lobe epileptic activity existing independently of neurological focal may share common neurobiological mechanism with dissociative symptoms. This conceptualization of dissociative phenomena is also in accordance with findings that originate from the study of the relationship between epilepsy and mental illness. The relationship was for the first time described in Meduna's concept of antagonism between epilepsy and psychosis and from the study of forced normalization introduced by Landolt in 1950s. The findings reported similar pathological conditions as in dissociative states when psychopathological symptoms and paroxysms may represent two different forms of the pathological process. Following the concept of forced normalization Tellenbach in 1965 introduced the term alternative psychosis implicating that stopping seizures does not mean vanishing or inactivity of the pathological state and that the epilepsy is still active subcortically and supplies energy for psychopathological symptoms. In the present review chaos in brain neural networks as a possible explanation of the relationship between dissociation and epileptic activity has been suggested that represents testable hypothesis for future research.

000      
00000naa 2200000 a 4500
001      
bmc10026392
003      
CZ-PrNML
005      
20140806141551.0
008      
101018s2007 sw e eng||
009      
AR
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sw
100    1_
$a Bob, Petr $7 uk2005277741 $u Center for Neuropsychiatric Research of Traumatic Stress and Department of Psychiatry, 1st Faculy of Medicine, Charles University, Prague, Czech Republic
245    10
$a Dissociation, forced normalization and dynamic multi-stability of the brain. / $c Petr Bob
314    __
$a Centre for Neuropsychiatric Research of Traumatic Stress & Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. petrbob@netscape.net
520    9_
$a Dissociated states represent pathological conditions where psychological trauma may emerge in a variety of forms such as psychic dissociative symptoms (hallucinations, derealization etc.) or on the other hand as somatoform symptoms (paroxysms, loss of motor control, involuntary movements etc.). Recent findings suggest that neurophysiological level of dissociative phenomena may be linked to the same neurophysiological principles that emerge in multi-stable perception of ambiguous stimuli likely caused by competing interpretations with mutual exclusivity. At this time there is evidence that temporal lobe seizure activity can produce dissociative syndrome and from these findings may be inferred that temporal lobe epileptic activity existing independently of neurological focal may share common neurobiological mechanism with dissociative symptoms. This conceptualization of dissociative phenomena is also in accordance with findings that originate from the study of the relationship between epilepsy and mental illness. The relationship was for the first time described in Meduna's concept of antagonism between epilepsy and psychosis and from the study of forced normalization introduced by Landolt in 1950s. The findings reported similar pathological conditions as in dissociative states when psychopathological symptoms and paroxysms may represent two different forms of the pathological process. Following the concept of forced normalization Tellenbach in 1965 introduced the term alternative psychosis implicating that stopping seizures does not mean vanishing or inactivity of the pathological state and that the epilepsy is still active subcortically and supplies energy for psychopathological symptoms. In the present review chaos in brain neural networks as a possible explanation of the relationship between dissociation and epileptic activity has been suggested that represents testable hypothesis for future research.
650    _2
$a mozek $x fyziologie $7 D001921
650    _2
$a vědomí $7 D003243
650    _2
$a disociační poruchy $x etiologie $x patofyziologie $x psychologie $7 D004213
650    _2
$a epilepsie temporálního laloku $x komplikace $7 D004833
650    _2
$a lidé $7 D006801
650    _2
$a paměť $7 D008568
650    _2
$a neuronové sítě $7 D016571
650    _2
$a psychotické poruchy $x patofyziologie $7 D011618
650    _2
$a financování organizované $7 D005381
655    _2
$a přehledy $7 D016454
773    0_
$w MED00168352 $t Neuro-endocrinology letters $g Roč. 28, č. 3 (2007), s. 231-246 $x 0172-780X
910    __
$a ABA008 $b x $y 7 $z 0
990    __
$a 20110112143016 $b ABA008
991    __
$a 20140806141912 $b ABA008
999    __
$a ok $b bmc $g 801497 $s 666246
BAS    __
$a 3
BMC    __
$a 2007 $b 28 $c 3 $d 231-246 $i 0172-780X $m Neuro-endocrinology letters $n Neuro-endocrinol. lett. $x MED00168352
GRA    __
$a NR8824 $p MZ0
LZP    __
$a 2010-B/mk

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...