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Asymmetry of basal ganglia in children with attention deficit hyperactivity disorder
P. Uhlíková, I. Paclt, M. Vaněčková, T. Morcinek, Z. Seidel, J. Krásenský, J. Daneš
Neuro-endocrinology letters.
2007 ;
28 (5) :
604-609.
Language English Country Sweden
Persistent link
https://www.medvik.cz/link/bmc10026393
Grant support
NR9534
MZ0
CEP Register
- MeSH
- Basal Ganglia abnormalities anatomy & histology pathology MeSH
- Child MeSH
- Financing, Organized MeSH
- Functional Laterality MeSH
- Attention Deficit Disorder with Hyperactivity drug therapy pathology MeSH
- Humans MeSH
- Methylphenidate therapeutic use MeSH
- Statistics, Nonparametric MeSH
- Caudate Nucleus abnormalities anatomy & histology pathology MeSH
- Reference Values MeSH
- Central Nervous System Stimulants therapeutic use MeSH
- Case-Control Studies MeSH
- Organ Size MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatry disorder with several key symptoms, such as inattentiveness, impulsivity and hyperactivity. Neuropsychiatry studies have implicated the frontostriatal circuit in the pathological physiology of the disorder. Using magnetic resonance imaging (MRI), we examined the basal ganglia in 13 ADHD patients and eight unaffected comparison children. The volume of caudate, putamen and globus pallidus was measured. In the ADHD patients, we detected an increased left > right asymmetry of the basal ganglia. This reversal of asymmetry in the globus pallidus and caudate nucleus were statistically significant. These finding provide further evidence of morphological brain abnormalities in ADHD.
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