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Asymmetry of basal ganglia in children with attention deficit hyperactivity disorder
P. Uhlíková, I. Paclt, M. Vaněčková, T. Morcinek, Z. Seidel, J. Krásenský, J. Daneš
Neuro-endocrinology letters.
2007 ;
28 (5) :
604-609.
Jazyk angličtina Země Švédsko
Perzistentní odkaz
https://www.medvik.cz/link/bmc10026393
Grantová podpora
NR9534
MZ0
CEP - Centrální evidence projektů
- MeSH
- bazální ganglia abnormality anatomie a histologie patologie MeSH
- dítě MeSH
- financování organizované MeSH
- funkční lateralita MeSH
- hyperkinetická porucha farmakoterapie patologie MeSH
- lidé MeSH
- methylfenidát terapeutické užití MeSH
- neparametrická statistika MeSH
- nucleus caudatus abnormality anatomie a histologie patologie MeSH
- referenční hodnoty MeSH
- stimulanty centrálního nervového systému terapeutické užití MeSH
- studie případů a kontrol MeSH
- velikost orgánu MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatry disorder with several key symptoms, such as inattentiveness, impulsivity and hyperactivity. Neuropsychiatry studies have implicated the frontostriatal circuit in the pathological physiology of the disorder. Using magnetic resonance imaging (MRI), we examined the basal ganglia in 13 ADHD patients and eight unaffected comparison children. The volume of caudate, putamen and globus pallidus was measured. In the ADHD patients, we detected an increased left > right asymmetry of the basal ganglia. This reversal of asymmetry in the globus pallidus and caudate nucleus were statistically significant. These finding provide further evidence of morphological brain abnormalities in ADHD.
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- $a Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatry disorder with several key symptoms, such as inattentiveness, impulsivity and hyperactivity. Neuropsychiatry studies have implicated the frontostriatal circuit in the pathological physiology of the disorder. Using magnetic resonance imaging (MRI), we examined the basal ganglia in 13 ADHD patients and eight unaffected comparison children. The volume of caudate, putamen and globus pallidus was measured. In the ADHD patients, we detected an increased left > right asymmetry of the basal ganglia. This reversal of asymmetry in the globus pallidus and caudate nucleus were statistically significant. These finding provide further evidence of morphological brain abnormalities in ADHD.
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