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Cardiac adaptation to chronic high-altitude hypoxia: beneficial and adverse effects
B Ostadal, F Kolar
Jazyk angličtina Země Nizozemsko
Typ dokumentu přehledy
NLK
ScienceDirect (archiv)
od 2002-01-01 do 2009-12-31
- MeSH
- aklimatizace fyziologie MeSH
- atmosférický tlak MeSH
- chronická nemoc MeSH
- financování organizované MeSH
- hypoxie komplikace metabolismus MeSH
- ischemie etiologie metabolismus MeSH
- kyslík krev MeSH
- myokard metabolismus MeSH
- nadmořská výška MeSH
- reperfuzní poškození myokardu etiologie metabolismus MeSH
- věkové faktory MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- přehledy MeSH
This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad spectrum of related issues, we focused on the development and reversibility of both beneficial and adverse adaptive myocardial changes. Particular attention was paid to cardioprotective effects of adaptation to chronic high-altitude hypoxia and their molecular mechanisms. Moreover, interspecies and age differences in the cardiac sensitivity to hypoxia-induced effects in various experimental models were emphasized.
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- $a Centre for Cardiovascular Research, Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic. ostadal@biomed.cas.cz
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- $a This review deals with the capability of the heart to adapt to chronic hypoxia in animals exposed to either natural or simulated high altitude. From the broad spectrum of related issues, we focused on the development and reversibility of both beneficial and adverse adaptive myocardial changes. Particular attention was paid to cardioprotective effects of adaptation to chronic high-altitude hypoxia and their molecular mechanisms. Moreover, interspecies and age differences in the cardiac sensitivity to hypoxia-induced effects in various experimental models were emphasized.
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