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Antibacterial activity of N-benzylsalicylthioamides
Petrlíková E, Waisser K, Jílek P, Dufková I.
Language English Country Czech Republic
- MeSH
- Anti-Bacterial Agents pharmacology chemistry MeSH
- Gram-Negative Bacteria drug effects MeSH
- Gram-Positive Cocci drug effects MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Thioamides pharmacology chemistry MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
The in-vitro biological activity of N-benzylsalicylthioamides against 8 bacterial strains was determined by broth microdilution method; results were compared with those obtained with neomycin, penicillin G, ciprofloxacin and penicillin V. The compounds showed moderate to high activity against G(+) bacteria; especially compounds 4, 6, 13, 16-21 and 24 exhibited comparable or higher activity than reference drugs. The antibacterial activity was analyzed by quantitative structure-activity relationship (QSAR). The antibacterial activity increased with lipophilicity, with the presence of halogens and with increasing value of Hammet substituent constant ?.
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Lit.: 4
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- $a The in-vitro biological activity of N-benzylsalicylthioamides against 8 bacterial strains was determined by broth microdilution method; results were compared with those obtained with neomycin, penicillin G, ciprofloxacin and penicillin V. The compounds showed moderate to high activity against G(+) bacteria; especially compounds 4, 6, 13, 16-21 and 24 exhibited comparable or higher activity than reference drugs. The antibacterial activity was analyzed by quantitative structure-activity relationship (QSAR). The antibacterial activity increased with lipophilicity, with the presence of halogens and with increasing value of Hammet substituent constant ?.
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