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Effects of early therapeutic administration of interleukin-1ß on survival rate and bone marrow hemopoiesis of irradiated mice

Alexander Grebenyuk, Victor Zatsepin, Natalia Aksenova, Alexander Timoshevsky

. 2010 ; 53 (4) : 221-224.

Jazyk angličtina Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc10037411

The study was aimed at the experimental assessment of the efficacy of recombinant interleukin-1ß in the early therapy of haemopoiesis disorders caused by X-ray irradiation. The efficacy of the product was based on the 30-day survival rate and average life expectancy of dead animals. Endogenous and exogenous colony-formations were studied to reveal possible mechanisms of therapeutic effects of interleukin-1ß on the bone marrow. The early administration (10–15 min after exposure to radiation) of recombinant interleukin-1ß in a dose of 50 µg/kg increased the survival rate and prevented the post-irradiation decrease in the number of endogenous and exogenous CFU-S9 in irradiated mice.

Citace poskytuje Crossref.org

Bibliografie atd.

Lit.: 11

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