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Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits
K Smejkal, S Chudik, P Kloucek, R Marek, J Cvacka, M Urbanova, O Julinek, L Kokoska, T Slapetova, P Holubova, A Zima, M Dvorska
Language English Country United States
Grant support
1A8666
MZ0
CEP Register
PubMed
18293924
DOI
10.1021/np070446u
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology chemistry isolation & purification MeSH
- Bacteria drug effects MeSH
- Candida albicans drug effects MeSH
- Circular Dichroism MeSH
- Financing, Organized MeSH
- Flavonoids pharmacology chemistry isolation & purification MeSH
- Plants, Medicinal chemistry MeSH
- Microbial Sensitivity Tests MeSH
- Molecular Structure MeSH
- Nuclear Magnetic Resonance, Biomolecular MeSH
- Fruit chemistry MeSH
- Scrophulariaceae chemistry MeSH
- Geographicals
- Czech Republic MeSH
Eight C-6-geranylflavonoids ( 1- 8) were isolated from an ethanol extract of Paulownia tomentosa fruits. Tomentodiplacone ( 1), 3'- O-methyl-5'-hydroxydiplacone ( 2), 3'- O-methyl-5'- O-methyldiplacone ( 3), and tomentodiplacone B ( 4) were obtained as new compounds, and 3'- O-methyldiplacol ( 5) was isolated for the first time from a natural source. The structures of these new compounds were determined by using mass spectrometry (including HRMS) and 1D and 2D NMR spectroscopy, and the absolute configurations of the compounds were determined by circular dichroism. The antibacterial activities of 1- 8 against seven bacteria and yeast were evaluated.
References provided by Crossref.org
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