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Absence of ethanol-induced interdigitation in supported phospholipid bilayers on silica surfaces
A Miszta, Deursen B van, R Schoufs, M Hof, WT Hermens
Jazyk angličtina Země Spojené státy americké
- MeSH
- adsorpce MeSH
- časové faktory MeSH
- ethanol chemie MeSH
- financování organizované MeSH
- fosfolipidy chemie MeSH
- lipidové dvojvrstvy chemie MeSH
- membrány umělé MeSH
- oxid křemičitý chemie MeSH
- povrchové vlastnosti MeSH
- teplota MeSH
Membranes prepared by the adsorption of phospholipid vesicles on solid supports are much-used model systems in biomedical research. However, there is accumulating evidence that such membranes may not always be equivalent to the free-standing cellular membranes that they are modeling. In the present study, sonicated DOPC/DOPS (80/20 mol %) vesicles were adsorbed on hydrophilic silica surfaces, a system that has been demonstrated to produce confluent bilayers. In addition, pure DOPC and DLPC membranes were studied. It is demonstrated that ethanol-induced membrane interdigitation, as demonstrated for free-standing bilayers, does not occur in these supported membranes.
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- $a Membranes prepared by the adsorption of phospholipid vesicles on solid supports are much-used model systems in biomedical research. However, there is accumulating evidence that such membranes may not always be equivalent to the free-standing cellular membranes that they are modeling. In the present study, sonicated DOPC/DOPS (80/20 mol %) vesicles were adsorbed on hydrophilic silica surfaces, a system that has been demonstrated to produce confluent bilayers. In addition, pure DOPC and DLPC membranes were studied. It is demonstrated that ethanol-induced membrane interdigitation, as demonstrated for free-standing bilayers, does not occur in these supported membranes.
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