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Building of RNA and DNA double helices into electron density
F Pavelcik, B Schneider
Language English Country Denmark
Document type Comparative Study, Validation Study
NLK
Wiley Online Library (archiv)
from 1993-01-01 to 2012-12-31
- MeSH
- DNA chemistry MeSH
- Financing, Organized MeSH
- Nucleic Acid Conformation MeSH
- Crystallography, X-Ray MeSH
- Models, Molecular MeSH
- Base Pairing MeSH
- Computer Simulation MeSH
- RNA chemistry MeSH
- Software MeSH
- Static Electricity MeSH
- Publication type
- Comparative Study MeSH
- Validation Study MeSH
A method has been developed that automatically fits double-helical regions into the electron density of nucleic acid structures. Rigid fragments consisting of two Watson-Crick base pairs and three pairs of phosphate groups in the A-type or B-type conformation are positioned into the electron density by phased rotation and translation functions. The position and orientation of the localized double-helical fragments are determined by phased refinement. The method has been tested by building double-helical regions of nine RNA structures of variable crystallographic resolution and polynucleotide length and is available for free use.
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- $a Building of RNA and DNA double helices into electron density / $c F Pavelcik, B Schneider
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- $a Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences in Brno, CZ-61242 Brno, Czech Republic. pavelcikf@vfu.cz
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- $a A method has been developed that automatically fits double-helical regions into the electron density of nucleic acid structures. Rigid fragments consisting of two Watson-Crick base pairs and three pairs of phosphate groups in the A-type or B-type conformation are positioned into the electron density by phased rotation and translation functions. The position and orientation of the localized double-helical fragments are determined by phased refinement. The method has been tested by building double-helical regions of nine RNA structures of variable crystallographic resolution and polynucleotide length and is available for free use.
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- $a DNA $x chemie $7 D004247
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