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The identity of the transcription +1 position is crucial for changes in gene expression in response to amino acid starvation in Bacillus subtilis
L. Krasny, H. Tiserova, J. Jonak, D. Rejman, H. Sanderova
Jazyk angličtina Země Grenada
NLK
Free Medical Journals
od 1997 do Před 18 měsíci
Wiley Online Library (archiv)
od 1997-01-01 do 2012-12-31
Wiley Free Content
od 1997 do Před 18 měsíci
- MeSH
- aminokyseliny metabolismus MeSH
- Bacillus subtilis genetika metabolismus MeSH
- bakteriální proteiny genetika MeSH
- financování organizované MeSH
- genetická transkripce MeSH
- nukleotidy metabolismus MeSH
- počátek transkripce MeSH
- promotorové oblasti (genetika) MeSH
- regulace genové exprese u bakterií MeSH
- sekvence nukleotidů MeSH
- sekvenční seřazení MeSH
We identify here a pattern in the transcription start sites (+1A or +1G) of sigma(A)-dependent promoters of genes that are up-/downregulated in response to amino acid starvation (stringent response) in Bacillus subtilis. Upregulated promoters initiate mostly with ATP and downregulated promoters with GTP. These promoters appear to be sensitive to changes in initiating nucleoside triphosphate concentrations. During the stringent response in B. subtilis, when ATP and GTP levels change reciprocally, the identity of the +1 position (A or G) of these promoters is a factor important in their regulation. Mutations that change the identity of position +1 (A for G and vice versa) change the response of the promoter to amino acid starvation.
Citace poskytuje Crossref.org
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